TACC2

Transforming, acidic coiled-coil containing protein 2, also known as TACC2, is a human gene.

PBB_Summary
section_title =
summary_text = Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.cite web | title = Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10579| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Still IH, Vince P, Cowell JK |title=The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. |journal=Genomics |volume=58 |issue= 2 |pages= 165–70 |year= 1999 |pmid= 10366448 |doi= 10.1006/geno.1999.5829
*cite journal | author=Still IH, Hamilton M, Vince P, "et al." |title=Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. |journal=Oncogene |volume=18 |issue= 27 |pages= 4032–8 |year= 1999 |pmid= 10435627 |doi= 10.1038/sj.onc.1202801
*cite journal | author=Gergely F, Kidd D, Jeffers K, "et al." |title=D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. |journal=Embo J. |volume=19 |issue= 2 |pages= 241–52 |year= 2000 |pmid= 10637228 |doi= 10.1093/emboj/19.2.241
*cite journal | author=Chen HM, Schmeichel KL, Mian IS, "et al." |title=AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression. |journal=Mol. Biol. Cell |volume=11 |issue= 4 |pages= 1357–67 |year= 2000 |pmid= 10749935 |doi=
*cite journal | author=Gergely F, Karlsson C, Still I, "et al." |title=The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14352–7 |year= 2001 |pmid= 11121038 |doi= 10.1073/pnas.97.26.14352
*cite journal | author=Pu JJ, Li C, Rodriguez M, Banerjee D |title=Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. |journal=Cytokine |volume=13 |issue= 3 |pages= 129–37 |year= 2001 |pmid= 11161455 |doi= 10.1006/cyto.2000.0812
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lauffart B, Gangisetty O, Still IH |title=Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. |journal=Genomics |volume=81 |issue= 2 |pages= 192–201 |year= 2003 |pmid= 12620397 |doi=10.1016/S0888-7543(02)00039-3
*cite journal | author=Sadek CM, Pelto-Huikko M, Tujague M, "et al." |title=TACC3 expression is tightly regulated during early differentiation. |journal=Gene Expr. Patterns |volume=3 |issue= 2 |pages= 203–11 |year= 2004 |pmid= 12711550 |doi=10.1016/S1567-133X(02)00066-2
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gangisetty O, Lauffart B, Sondarva GV, "et al." |title=The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. |journal=Oncogene |volume=23 |issue= 14 |pages= 2559–63 |year= 2004 |pmid= 14767476 |doi= 10.1038/sj.onc.1207424
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P |title=Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. |journal=BMC Evol. Biol. |volume=4 |issue= |pages= 16 |year= 2004 |pmid= 15207008 |doi= 10.1186/1471-2148-4-16
*cite journal | author=Dou Z, Ding X, Zereshki A, "et al." |title=TTK kinase is essential for the centrosomal localization of TACC2. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 51–6 |year= 2004 |pmid= 15304323 |doi= 10.1016/j.febslet.2004.06.092
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240

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