ORC5L

ORC5L
Origin recognition complex, subunit 5
Identifiers
Symbols ORC5; ORC5L; ORC5P; ORC5T
External IDs OMIM602331 MGI1347044 HomoloGene37636 GeneCards: ORC5 Gene
RNA expression pattern
PBB GE ORC5L 204957 at tn.png
PBB GE ORC5L 211212 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5001 26429
Ensembl ENSG00000164815 ENSMUSG00000029012
UniProt O43913 Q9WUV0
RefSeq (mRNA) NM_002553.3 NM_011959.2
RefSeq (protein) NP_002544.1 NP_036089.1
Location (UCSC) Chr 7:
103.77 – 103.85 Mb
Chr 5:
21.99 – 22.06 Mb
PubMed search [1] [2]

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5L gene.[1][2][3]

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]

Interactions

ORC5L has been shown to interact with ORC1L,[4] ORC2L,[4][5][6][7] MCM7,[4] ORC4L,[4][5][6] ORC3L,[4][6][8][7] MCM2,[4] MCM4[4] and MCM3.[4]

References

  1. ^ Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T (Feb 1998). "Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22". Genomics 46 (2): 294–8. doi:10.1006/geno.1997.5003. PMID 9417919. 
  2. ^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Jan 1999). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". J Biol Chem 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972. 
  3. ^ a b "Entrez Gene: ORC5L origin recognition complex, subunit 5-like (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5001. 
  4. ^ a b c d e f g h Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ^ a b Quintana, D G; Thome K C, Hou Z H, Ligon A H, Morton C C, Dutta A (Oct. 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. (UNITED STATES) 273 (42): 27137–45. doi:10.1074/jbc.273.42.27137. ISSN 0021-9258. PMID 9765232. 
  6. ^ a b c Dhar, S K; Delmolino L, Dutta A (Aug. 2001). "Architecture of the human origin recognition complex". J. Biol. Chem. (United States) 276 (31): 29067–71. doi:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502. 
  7. ^ a b Vashee, S; Simancek P, Challberg M D, Kelly T J (Jul. 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 
  8. ^ Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May. 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron (UNITED STATES) 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. ISSN 0896-6273. PMID 10402192. 

Further reading


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Look at other dictionaries:

  • ORC2L — Origin recognition complex, subunit 2 Identifiers Symbols ORC2; ORC2 External IDs OM …   Wikipedia

  • ORC4L — Origin recognition complex, subunit 4 Identifiers Symbols ORC4; FLJ46668; ORC4L; ORC4P External IDs …   Wikipedia

  • ORC3L — Origin recognition complex, subunit 3 Identifiers Symbols ORC3; LAT; LATHEO; ORC3L External IDs …   Wikipedia

  • ORC1 — Origin recognition complex, subunit 1 Identifiers Symbols ORC1; HSORC1; ORC1L; PARC1 External IDs …   Wikipedia

  • MCM7 — Proteína 7 de mantenimiento de mini cromosomas (S. cerevisiae) HUGO 6950 Símbolo MCM7 Símbolos alt. MCM2; CDA …   Wikipedia Español

  • ORC1L — Subunidad 1 del complejo de reconocimiento de origen HUGO 8487 Símbolo ORC1L Símbolos alt. HSORC1, ORC1, PARC1 …   Wikipedia Español

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