Vascular endothelial growth inhibitor

Vascular endothelial growth inhibitor

Vascular endothelial growth inhibitor (VEGI) is an anti-angiogenic [ [http://www.ihop-net.org/UniPub/iHOP/gs/95120.html Hoffmann, R., Valencia, A. A gene network for navigating the literature. Nature Genetics 36, 664 (2004)] ] protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. TNFSF15 is the human gene for it.cite web | title = Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9966| accessdate = ]

Gene

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.cite web | title = Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9966| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rubinstein MH |title=A new granulation method for compressed tablets [proceedings] . |journal=J. Pharm. Pharmacol. |volume=28 Suppl |issue= |pages= 67P |year= 1977 |pmid= 12345 |doi=
*cite journal | author=Tan KB, Harrop J, Reddy M, "et al." |title=Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. |journal=Gene |volume=204 |issue= 1-2 |pages= 35–46 |year= 1998 |pmid= 9434163 |doi=
*cite journal | author=Zhai Y, Ni J, Jiang GW, "et al." |title=VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. |journal=FASEB J. |volume=13 |issue= 1 |pages= 181–9 |year= 1999 |pmid= 9872942 |doi=
*cite journal | author=Yue TL, Ni J, Romanic AM, "et al." |title=TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1479–86 |year= 1999 |pmid= 9880523 |doi=
*cite journal | author=Haridas V, Shrivastava A, Su J, "et al." |title=VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. |journal=Oncogene |volume=18 |issue= 47 |pages= 6496–504 |year= 2000 |pmid= 10597252 |doi= 10.1038/sj.onc.1203059
*cite journal | author=Yu J, Tian S, Metheny-Barlow L, "et al." |title=Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor. |journal=Circ. Res. |volume=89 |issue= 12 |pages= 1161–7 |year= 2002 |pmid= 11739281 |doi=
*cite journal | author=Migone TS, Zhang J, Luo X, "et al." |title=TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. |journal=Immunity |volume=16 |issue= 3 |pages= 479–92 |year= 2002 |pmid= 11911831 |doi=
*cite journal | author=Chew LJ, Pan H, Yu J, "et al." |title=A novel secreted splice variant of vascular endothelial cell growth inhibitor. |journal=FASEB J. |volume=16 |issue= 7 |pages= 742–4 |year= 2002 |pmid= 11923219 |doi= 10.1096/fj.01-0757fje
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wen L, Zhuang L, Luo X, Wei P |title=TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39251–8 |year= 2003 |pmid= 12882979 |doi= 10.1074/jbc.M305833200
*cite journal | author=Bamias G, Martin C, Marini M, "et al." |title=Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. |journal=J. Immunol. |volume=171 |issue= 9 |pages= 4868–74 |year= 2004 |pmid= 14568967 |doi=
*cite journal | author=Prehn JL, Mehdizadeh S, Landers CJ, "et al." |title=Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. |journal=Clin. Immunol. |volume=112 |issue= 1 |pages= 66–77 |year= 2004 |pmid= 15207783 |doi= 10.1016/j.clim.2004.02.007
*cite journal | author=Kang YJ, Kim WJ, Bae HU, "et al." |title=Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis. |journal=Cytokine |volume=29 |issue= 5 |pages= 229–35 |year= 2005 |pmid= 15760679 |doi= 10.1016/j.cyto.2004.12.001
*cite journal | author=Hou W, Medynski D, Wu S, "et al." |title=VEGI-192, a new isoform of TNFSF15, specifically eliminates tumor vascular endothelial cells and suppresses tumor growth. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5595–602 |year= 2006 |pmid= 16061878 |doi= 10.1158/1078-0432.CCR-05-0384
*cite journal | author=Yamazaki K, McGovern D, Ragoussis J, "et al." |title=Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. |journal=Hum. Mol. Genet. |volume=14 |issue= 22 |pages= 3499–506 |year= 2006 |pmid= 16221758 |doi= 10.1093/hmg/ddi379
*cite journal | author=Yao JJ, Zhang M, Miao XH, "et al." |title=Isoform of vascular endothelial cell growth inhibitor (VEGI72-251) increases interleukin-2 production by activation of T lymphocytes. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=38 |issue= 4 |pages= 249–53 |year= 2006 |pmid= 16604264 |doi=
*cite journal | author=Prehn JL, Thomas LS, Landers CJ, "et al." |title=The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. |journal=J. Immunol. |volume=178 |issue= 7 |pages= 4033–8 |year= 2007 |pmid= 17371957 |doi=
*cite journal | author=Cassatella MA, Pereira-da-Silva G, da Silva GP, "et al." |title=Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7325–33 |year= 2007 |pmid= 17513783 |doi=
*cite journal | author=Jin T, Guo F, Kim S, "et al." |title=X-ray crystal structure of TNF ligand family member TL1A at 2.1A. |journal=Biochem. Biophys. Res. Commun. |volume=364 |issue= 1 |pages= 1–6 |year= 2007 |pmid= 17935696 |doi= 10.1016/j.bbrc.2007.09.097

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