WASF3

WAS protein family, member 3, also known as WASF3, is a human gene.cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jones GE |title=Cellular signaling in macrophage migration and chemotaxis. |journal=J. Leukoc. Biol. |volume=68 |issue= 5 |pages= 593–602 |year= 2000 |pmid= 11073096 |doi=
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Schott DR, Chang JN, Deng G, "et al." |title=A candidate tumor suppressor gene in human breast cancers. |journal=Cancer Res. |volume=54 |issue= 6 |pages= 1393–6 |year= 1994 |pmid= 8137235 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325–35 |year= 1998 |pmid= 9732292 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296–302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894
*cite journal | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590
*cite journal | author=Millard TH, Machesky LM |title=The Wiskott-Aldrich syndrome protein (WASP) family. |journal=Trends Biochem. Sci. |volume=26 |issue= 3 |pages= 198–9 |year= 2001 |pmid= 11246027 |doi=
*cite journal | author=Sossey-Alaoui K, Su G, Malaj E, "et al." |title=WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. |journal=Oncogene |volume=21 |issue= 38 |pages= 5967–74 |year= 2002 |pmid= 12185600 |doi= 10.1038/sj.onc.1205734
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sossey-Alaoui K, Head K, Nowak N, Cowell JK |title=Genomic organization and expression profile of the human and mouse WAVE gene family. |journal=Mamm. Genome |volume=14 |issue= 5 |pages= 314–22 |year= 2003 |pmid= 12856283 |doi= 10.1007/s00335-002-2247-7
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Oda A, Miki H, Wada I, "et al." |title=WAVE/Scars in platelets. |journal=Blood |volume=105 |issue= 8 |pages= 3141–8 |year= 2005 |pmid= 15280206 |doi= 10.1182/blood-2003-04-1319
*cite journal | author=Kashiwagi H, Shiraga M, Kato H, "et al." |title=Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage. |journal=J. Thromb. Haemost. |volume=3 |issue= 2 |pages= 361–8 |year= 2005 |pmid= 15670045 |doi= 10.1111/j.1538-7836.2004.01082.x
*cite journal | author=Stovold CF, Millard TH, Machesky LM |title=Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 11 |year= 2006 |pmid= 15752430 |doi= 10.1186/1471-2121-6-11
*cite journal | author=Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK |title=WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21748–55 |year= 2005 |pmid= 15826941 |doi= 10.1074/jbc.M500503200
*cite journal | author=Sossey-Alaoui K, Ranalli TA, Li X, "et al." |title=WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. |journal=Exp. Cell Res. |volume=308 |issue= 1 |pages= 135–45 |year= 2005 |pmid= 15907837 |doi= 10.1016/j.yexcr.2005.04.011

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