- CDSN
Corneodesmosin, also known as CDSN, is a human
gene .cite web | title = Entrez Gene: CDSN corneodesmosin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1041| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.cite web | title = Entrez Gene: CDSN corneodesmosin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1041| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Toribio J, Quiñones PA |title=Hereditary hypotrichosis simplex of the scalp. Evidence for autosomal dominant inheritance. |journal=Br. J. Dermatol. |volume=91 |issue= 6 |pages= 687–96 |year= 1975 |pmid= 4141628 |doi=
*cite journal | author=Lundström A, Serre G, Haftek M, Egelrud T |title=Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation. |journal=Arch. Dermatol. Res. |volume=286 |issue= 7 |pages= 369–75 |year= 1995 |pmid= 7818278 |doi=
*cite journal | author=Zhou Y, Chaplin DD |title=Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9470–4 |year= 1993 |pmid= 8415725 |doi=
*cite journal | author=Simon M, Montézin M, Guerrin M, "et al." |title=Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31770–6 |year= 1998 |pmid= 9395522 |doi=
*cite journal | author=Guerrin M, Simon M, Montézin M, "et al." |title=Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22640–7 |year= 1998 |pmid= 9712893 |doi=
*cite journal | author=Jenisch S, Koch S, Henseler T, "et al." |title=Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris. |journal=Tissue Antigens |volume=54 |issue= 5 |pages= 439–49 |year= 2000 |pmid= 10599883 |doi=
*cite journal | author=Guerrin M, Vincent C, Simon M, "et al." |title=Identification of six novel polymorphisms in the human corneodesmosin gene. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 32–8 |year= 2001 |pmid= 11169256 |doi=
*cite journal | author=Simon M, Jonca N, Guerrin M, "et al." |title=Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20292–9 |year= 2001 |pmid= 11279026 |doi= 10.1074/jbc.M100201200
*cite journal | author=Jonca N, Guerrin M, Hadjiolova K, "et al." |title=Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5024–9 |year= 2002 |pmid= 11739386 |doi= 10.1074/jbc.M108438200
*cite journal | author=Hui J, Oka A, Tamiya G, "et al." |title=Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis. |journal=Tissue Antigens |volume=60 |issue= 1 |pages= 77–83 |year= 2003 |pmid= 12366786 |doi=
*cite journal | author=Orrù S, Giuressi E, Casula M, "et al." |title=Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN). |journal=Tissue Antigens |volume=60 |issue= 4 |pages= 292–8 |year= 2003 |pmid= 12472658 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Levy-Nissenbaum E, Betz RC, Frydman M, "et al." |title=Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin. |journal=Nat. Genet. |volume=34 |issue= 2 |pages= 151–3 |year= 2003 |pmid= 12754508 |doi= 10.1038/ng1163
*cite journal | author=Caubet C, Jonca N, Lopez F, "et al." |title=Homo-oligomerization of human corneodesmosin is mediated by its N-terminal glycine loop domain. |journal=J. Invest. Dermatol. |volume=122 |issue= 3 |pages= 747–54 |year= 2004 |pmid= 15086562 |doi= 10.1111/j.0022-202X.2004.22331.x
*cite journal | author=Caubet C, Jonca N, Brattsand M, "et al." |title=Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1235–44 |year= 2004 |pmid= 15140227 |doi= 10.1111/j.0022-202X.2004.22512.x
*cite journal | author=Capon F, Allen MH, Ameen M, "et al." |title=A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. |journal=Hum. Mol. Genet. |volume=13 |issue= 20 |pages= 2361–8 |year= 2005 |pmid= 15333584 |doi= 10.1093/hmg/ddh273
*cite journal | author=Yang T, Liang D, Koch PJ, "et al." |title=Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. |journal=Genes Dev. |volume=18 |issue= 19 |pages= 2354–8 |year= 2004 |pmid= 15466487 |doi= 10.1101/gad.1232104
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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