HM13

HM13

Histocompatibility (minor) 13, also known as HM13, is a human gene.cite web | title = Entrez Gene: HM13 histocompatibility (minor) 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81502| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.cite web | title = Entrez Gene: HM13 histocompatibility (minor) 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81502| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lemberg MK, Bland FA, Weihofen A, "et al." |title=Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6441–6 |year= 2002 |pmid= 11714810 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Weihofen A, Binns K, Lemberg MK, "et al." |title=Identification of signal peptide peptidase, a presenilin-type aspartic protease. |journal=Science |volume=296 |issue= 5576 |pages= 2215–8 |year= 2002 |pmid= 12077416 |doi= 10.1126/science.1070925
*cite journal | author=Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI |title=Novel class of polytopic proteins with domains associated with putative protease activity. |journal=Biochemistry Mosc. |volume=67 |issue= 7 |pages= 826–35 |year= 2003 |pmid= 12139484 |doi=
*cite journal | author=McLauchlan J, Lemberg MK, Hope G, Martoglio B |title=Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets. |journal=EMBO J. |volume=21 |issue= 15 |pages= 3980–8 |year= 2002 |pmid= 12145199 |doi= 10.1093/emboj/cdf414
*cite journal | author=Lemberg MK, Martoglio B |title=Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis. |journal=Mol. Cell |volume=10 |issue= 4 |pages= 735–44 |year= 2002 |pmid= 12419218 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Urny J, Hermans-Borgmeyer I, Gercken G, Schaller HC |title=Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development. |journal=Gene Expr. Patterns |volume=3 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 12972007 |doi=
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Nyborg AC, Kornilova AY, Jansen K, "et al." |title=Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15153–60 |year= 2004 |pmid= 14704149 |doi= 10.1074/jbc.M309305200
*cite journal | author=Moliaka YK, Grigorenko A, Madera D, Rogaev EI |title=Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein. |journal=FEBS Lett. |volume=557 |issue= 1-3 |pages= 185–92 |year= 2004 |pmid= 14741365 |doi=
*cite journal | author=Soares MR, Bisch PM, Campos de Carvalho AC, "et al." |title=Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis. |journal=FEBS Lett. |volume=560 |issue= 1-3 |pages= 134–40 |year= 2004 |pmid= 14988012 |doi= 10.1016/S0014-5793(04)00088-2
*cite journal | author=Friedmann E, Lemberg MK, Weihofen A, "et al." |title=Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50790–8 |year= 2005 |pmid= 15385547 |doi= 10.1074/jbc.M407898200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Urny J, Hermans-Borgmeyer I, Schaller HC |title=Cell-surface expression of a new splice variant of the mouse signal peptide peptidase. |journal=Biochim. Biophys. Acta |volume=1759 |issue= 3-4 |pages= 159–65 |year= 2006 |pmid= 16730383 |doi= 10.1016/j.bbaexp.2006.02.007
*cite journal | author=Loureiro J, Lilley BN, Spooner E, "et al." |title=Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. |journal=Nature |volume=441 |issue= 7095 |pages= 894–7 |year= 2006 |pmid= 16738546 |doi= 10.1038/nature04830
*cite journal | author=Sato T, Nyborg AC, Iwata N, "et al." |title=Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. |journal=Biochemistry |volume=45 |issue= 28 |pages= 8649–56 |year= 2006 |pmid= 16834339 |doi= 10.1021/bi060597g

PBB_Controls
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