SEMG2

Semenogelin II, also known as SEMG2, is a human gene.

PBB_Summary
section_title =
summary_text = The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.cite web | title = Entrez Gene: SEMG2 semenogelin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6407| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ulvsbäck M, Lazure C, Lilja H, "et al." |title=Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 18080–4 |year= 1992 |pmid= 1517240 |doi=
*cite journal | author=Lilja H, Lundwall A |title=Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4559–63 |year= 1992 |pmid= 1584792 |doi=10.1073/pnas.89.10.4559
*cite journal | author=Schneider K, Kausler W, Tripier D, "et al." |title= [Isolation and structure determination of two peptides occurring in human seminal plasma] |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 4 |pages= 353–6 |year= 1989 |pmid= 2757795 |doi=
*cite journal | author=Lundwall A |title=The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA. |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 466–70 |year= 1996 |pmid= 8654389 |doi=10.1111/j.1432-1033.1996.00466.x
*cite journal | author=Malm J, Hellman J, Magnusson H, "et al." |title=Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 48–53 |year= 1996 |pmid= 8665951 |doi=10.1111/j.1432-1033.1996.0048q.x
*cite journal | author=Kise H, Nishioka J, Kawamura J, Suzuki K |title=Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 88–96 |year= 1996 |pmid= 8665956 |doi=10.1111/j.1432-1033.1996.0088q.x
*cite journal | author=Bjartell A, Malm J, Moller C, "et al." |title=Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry. |journal=J. Androl. |volume=17 |issue= 1 |pages= 17–26 |year= 1997 |pmid= 8833737 |doi=
*cite journal | author=Ulvsbäck M, Lundwall A |title=Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon. |journal=Eur. J. Biochem. |volume=245 |issue= 1 |pages= 25–31 |year= 1997 |pmid= 9128720 |doi=10.1111/j.1432-1033.1997.00025.x
*cite journal | author=Peter A, Lilja H, Lundwall A, Malm J |title=Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. |journal=Eur. J. Biochem. |volume=252 |issue= 2 |pages= 216–21 |year= 1998 |pmid= 9523691 |doi=10.1046/j.1432-1327.1998.2520216.x
*cite journal | author=Lövgren J, Airas K, Lilja H |title=Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors. |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 781–9 |year= 1999 |pmid= 10411640 |doi=10.1046/j.1432-1327.1999.00433.x
*cite journal | author=Malm J, Hellman J, Hogg P, Lilja H |title=Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor. |journal=Prostate |volume=45 |issue= 2 |pages= 132–9 |year= 2000 |pmid= 11027412 |doi=10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Brillard-Bourdet M, Réhault S, Juliano L, "et al." |title=Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. |journal=Eur. J. Biochem. |volume=269 |issue= 1 |pages= 390–5 |year= 2002 |pmid= 11784334 |doi=10.1046/j.0014-2956.2001.02667.x
*cite journal | author=Lundwall A, Bjartell A, Olsson AY, Malm J |title=Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 805–10 |year= 2003 |pmid= 12200457 |doi=10.1093/molehr/8.9.805
*cite journal | author=Ek P, Malm J, Lilja H, "et al." |title=Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen. |journal=J. Androl. |volume=23 |issue= 6 |pages= 806–14 |year= 2003 |pmid= 12399526 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yoshida K, Yamasaki T, Yoshiike M, "et al." |title=Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma. |journal=J. Androl. |volume=24 |issue= 6 |pages= 878–84 |year= 2004 |pmid= 14581514 |doi=
*cite journal | author=Jensen-Seaman MI, Li WH |title=Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. |journal=J. Mol. Evol. |volume=57 |issue= 3 |pages= 261–70 |year= 2004 |pmid= 14629036 |doi= 10.1007/s00239-003-2474-x
*cite journal | author=Dorus S, Evans PD, Wyckoff GJ, "et al." |title=Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. |journal=Nat. Genet. |volume=36 |issue= 12 |pages= 1326–9 |year= 2005 |pmid= 15531881 |doi= 10.1038/ng1471
*cite journal | author=Jonsson M, Linse S, Frohm B, "et al." |title=Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. |journal=Biochem. J. |volume=387 |issue= Pt 2 |pages= 447–53 |year= 2005 |pmid= 15563730 |doi= 10.1042/BJ20041424

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