SFRP2

Secreted frizzled-related protein 2, also known as SFRP2, is a human gene.cite web | title = Entrez Gene: SFRP2 secreted frizzled-related protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6423| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.cite web | title = Entrez Gene: SFRP2 secreted frizzled-related protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6423| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rattner A, Hsieh JC, Smallwood PM, "et al." |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859–63 |year= 1997 |pmid= 9096311 |doi=
*cite journal | author=Melkonyan HS, Chang WC, Shapiro JP, "et al." |title=SARPs: a family of secreted apoptosis-related proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13636–41 |year= 1998 |pmid= 9391078 |doi=
*cite journal | author=Hu E, Zhu Y, Fredrickson T, "et al." |title=Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 287–93 |year= 1998 |pmid= 9642118 |doi= 10.1006/bbrc.1998.8784
*cite journal | author=Lescher B, Haenig B, Kispert A |title=sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. |journal=Dev. Dyn. |volume=213 |issue= 4 |pages= 440–51 |year= 1999 |pmid= 9853965 |doi= 10.1002/(SICI)1097-0177(199812)213:4<440::AID-AJA9>3.0.CO;2-6 |doilabel=10.1002/(SICI)1097-0177(199812)213:4440::AID-AJA93.0.CO;2-6
*cite journal | author=Chang JT, Esumi N, Moore K, "et al." |title=Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 575–83 |year= 1999 |pmid= 10072424 |doi=
*cite journal | author=Lee CS, Buttitta LA, May NR, "et al." |title=SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. |journal=Development |volume=127 |issue= 1 |pages= 109–18 |year= 2000 |pmid= 10654605 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Brophy PD, Lang KM, Dressler GR |title=The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52401–5 |year= 2004 |pmid= 14561758 |doi= 10.1074/jbc.M305614200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lee JL, Lin CT, Chueh LL, Chang CJ |title=Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14602–9 |year= 2004 |pmid= 14709558 |doi= 10.1074/jbc.M309008200
*cite journal | author=Müller HM, Oberwalder M, Fiegl H, "et al." |title=Methylation changes in faecal DNA: a marker for colorectal cancer screening? |journal=Lancet |volume=363 |issue= 9417 |pages= 1283–5 |year= 2004 |pmid= 15094274 |doi= 10.1016/S0140-6736(04)16002-9
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Clément G, Braunschweig R, Pasquier N, "et al." |title=Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. |journal=Oncogene |volume=25 |issue= 21 |pages= 3084–92 |year= 2006 |pmid= 16407829 |doi= 10.1038/sj.onc.1209338
*cite journal | author=Urakami S, Shiina H, Enokida H, "et al." |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Huang ZH, Li LH, Yang F, Wang JF |title=Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. |journal=World J. Gastroenterol. |volume=13 |issue= 6 |pages= 950–4 |year= 2007 |pmid= 17352030 |doi=

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