SNX9

Sorting nexin 9, also known as SNX9, is a human gene.cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Howard L, Nelson KK, Maciewicz RA, Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693–9 |year= 1999 |pmid= 10531379 |doi=
*cite journal | author=Teasdale RD, Loci D, Houghton F, "et al." |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7–16 |year= 2001 |pmid= 11485546 |doi=
*cite journal | author=Lin Q, Lo CG, Cerione RA, Yang W |title=The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10134–8 |year= 2002 |pmid= 11799118 |doi= 10.1074/jbc. M110329200
*cite journal | author=Lundmark R, Carlsson SR |title=The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2. |journal=Biochem. J. |volume=362 |issue= Pt 3 |pages= 597–607 |year= 2002 |pmid= 11879186 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lundmark R, Carlsson SR |title=Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46772–81 |year= 2004 |pmid= 12952949 |doi= 10.1074/jbc. M307334200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Schulze WX, Mann M |title=A novel proteomic screen for peptide-protein interactions. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10756–64 |year= 2004 |pmid= 14679214 |doi= 10.1074/jbc. M309909200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Lundmark R, Carlsson SR |title=Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42694–702 |year= 2004 |pmid= 15299020 |doi= 10.1074/jbc. M407430200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Soulet F, Yarar D, Leonard M, Schmid SL |title=SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=16 |issue= 4 |pages= 2058–67 |year= 2005 |pmid= 15703209 |doi= 10.1091/mbc. E04-11-1016
*cite journal | author=Yeow-Fong L, Lim L, Manser E |title=SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. |journal=FEBS Lett. |volume=579 |issue= 22 |pages= 5040–8 |year= 2005 |pmid= 16137687 |doi= 10.1016/j.febslet.2005.07.093
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Childress C, Lin Q, Yang W |title=Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 693–8 |year= 2006 |pmid= 16316319 |doi= 10.1042/BJ20050576
*cite journal | author=Marchès O, Batchelor M, Shaw RK, "et al." |title=EspF of enteropathogenic Escherichia coli binds sorting nexin 9. |journal=J. Bacteriol. |volume=188 |issue= 8 |pages= 3110–5 |year= 2006 |pmid= 16585770 |doi= 10.1128/JB.188.8.3110-3115.2006
*cite journal | author=Schmid EM, Ford MG, Burtey A, "et al." |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262
*cite journal | author=Badour K, McGavin MK, Zhang J, "et al." |title=Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 5 |pages= 1593–8 |year= 2007 |pmid= 17242350 |doi= 10.1073/pnas.0610543104
*cite journal | author=Yarar D, Waterman-Storer CM, Schmid SL |title=SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. |journal=Dev. Cell |volume=13 |issue= 1 |pages= 43–56 |year= 2007 |pmid= 17609109 |doi= 10.1016/j.devcel.2007.04.014

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