PEG10

PEG10
Paternally expressed 10
Identifiers
Symbols PEG10; EDR; HB-1; KIAA1051; MEF3L; Mar2; Mart2; RGAG3
External IDs OMIM609810 MGI2157785 HomoloGene116067 GeneCards: PEG10 Gene
RNA expression pattern
PBB GE PEG10 212092 at tn.png
PBB GE PEG10 212094 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23089 170676
Ensembl ENSG00000242265 ENSMUSG00000092035
UniProt Q86TG7 n/a
RefSeq (mRNA) NM_001040152.1 NM_001040611
RefSeq (protein) NP_001035242.1 NP_001035701
Location (UCSC) Chr 7:
94.29 – 94.3 Mb
Chr 6:
4.7 – 4.71 Mb
PubMed search [1] [2]

Retrotransposon-derived protein PEG10 is a protein that in humans is encoded by the PEG10 gene.[1][2][3][4]

This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.[4]

Interactions

PEG10 has been shown to interact with SIAH2[5] and SIAH1.[5]

References

  1. ^ Ono R, Kobayashi S, Wagatsuma H, Aisaka K, Kohda T, Kaneko-Ishino T, Ishino F (Apr 2001). "A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21". Genomics 73 (2): 232–7. doi:10.1006/geno.2001.6494. PMID 11318613. 
  2. ^ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091. 
  3. ^ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res 110 (1-4): 307–17. doi:10.1159/000084963. PMID 16093683. 
  4. ^ a b "Entrez Gene: PEG10 paternally expressed 10". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23089. 
  5. ^ a b Okabe, Hiroshi; Satoh Seiji, Furukawa Yoichi, Kato Tatsushi, Hasegawa Suguru, Nakajima Yumi, Yamaoka Yoshio, Nakamura Yusuke (Jun. 2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Res. (United States) 63 (12): 3043–8. ISSN 0008-5472. PMID 12810624. 

Further reading


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