SHANK2

SH3 and multiple ankyrin repeat domains 2, also known as SHANK2, is a human gene.cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.cite web | title = Entrez Gene: SHANK2 SH3 and multiple ankyrin repeat domains 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22941| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sheng M, Kim E |title=The Shank family of scaffold proteins. |journal=J. Cell. Sci. |volume=113 ( Pt 11) |issue= |pages= 1851–6 |year= 2000 |pmid= 10806096 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Du Y, Weed SA, Xiong WC, "et al." |title=Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5838–51 |year= 1998 |pmid= 9742101 |doi=
*cite journal | author=Zitzer H, Richter D, Kreienkamp HJ |title=Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18153–6 |year= 1999 |pmid= 10373412 |doi=
*cite journal | author=Tu JC, Xiao B, Naisbitt S, "et al." |title=Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. |journal=Neuron |volume=23 |issue= 3 |pages= 583–92 |year= 1999 |pmid= 10433269 |doi=
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Lim S, Naisbitt S, Yoon J, "et al." |title=Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29510–8 |year= 1999 |pmid= 10506216 |doi=
*cite journal | author=Boeckers TM, Winter C, Smalla KH, "et al." |title=Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 247–52 |year= 1999 |pmid= 10527873 |doi= 10.1006/bbrc.1999.1489
*cite journal | author=Kreienkamp HJ, Zitzer H, Gundelfinger ED, "et al." |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387–90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200
*cite journal | author=Kreienkamp HJ, Zitzer H, Richter D |title=Identification of proteins interacting with the rat somatostatin receptor subtype 2. |journal=J. Physiol. Paris |volume=94 |issue= 3-4 |pages= 193–8 |year= 2001 |pmid= 11087996 |doi=
*cite journal | author=Okamoto PM, Gamby C, Wells D, "et al." |title=Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48458–65 |year= 2002 |pmid= 11583995 |doi= 10.1074/jbc.M104927200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Soltau M, Richter D, Kreienkamp HJ |title=The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 575–83 |year= 2003 |pmid= 12504591 |doi=
*cite journal | author=Park E, Na M, Choi J, "et al." |title=The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19220–9 |year= 2003 |pmid= 12626503 |doi= 10.1074/jbc.M301052200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Han W, Kim KH, Jo MJ, "et al." |title=Shank2 associates with and regulates Na+/H+ exchanger 3. |journal=J. Biol. Chem. |volume=281 |issue= 3 |pages= 1461–9 |year= 2006 |pmid= 16293618 |doi= 10.1074/jbc.M509786200
*cite journal | author=Taylor TD, Noguchi H, Totoki Y, "et al." |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632

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