NDEL1

NudE nuclear distribution gene E homolog (A. nidulans)-like 1
Identifiers
Symbols	NDEL1; DKFZp451M0318; EOPA; MITAP1; NUDEL
External IDs	OMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1 Gene
Gene Ontology Molecular function • protein binding • microtubule binding • protein complex binding • alpha-tubulin binding • beta-tubulin binding • oligopeptidase activity Cellular component • kinetochore • condensed chromosome kinetochore • nuclear envelope • chromosome • cytoplasm • centrosome • spindle • cytosol • cytoskeleton • kinesin complex • microtubule • axon • cell leading edge • cell body • neurofilament cytoskeleton Biological process • M phase of mitotic cell cycle • microtubule cytoskeleton organization • mitotic prometaphase • mitotic cell cycle • neuron migration • inner cell mass cell proliferation • transport • chromosome segregation • multicellular organismal development • nervous system development • retrograde axon cargo transport • regulation of neuron projection development • central nervous system neuron axonogenesis • cell differentiation • activation of Cdc42 GTPase activity • positive regulation of axon extension • vesicle transport along microtubule • positive regulation of axon regeneration • nuclear envelope disassembly • centrosome localization • neurofilament cytoskeleton organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81565	83431
Ensembl	ENSG00000166579	ENSMUSG00000018736
UniProt	Q9GZM8	Q9ERR1
RefSeq (mRNA)	NM_001025579.1	NM_023668.2
RefSeq (protein)	NP_001020750.1	NP_076157.2
Location (UCSC)	Chr 17: 8.34 – 8.38 Mb	Chr 11: 68.63 – 68.69 Mb
PubMed search	[1]	[2]

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[1][2][3]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

Interactions

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[1] YWHAE,^[4] PAFAH1B1^[1][4] and DISC1.^[5][6]

References

1. ^ ^{a b c} Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Feb 2001). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260. 
2. ^ Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Feb 2001). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259. 
3. ^ ^{a b} "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81565. 
4. ^ ^{a b} Toyo-oka, Kazuhito; Shionoya Aki, Gambello Michael J, Cardoso Carlos, Leventer Richard, Ward Heather L, Ayala Ramses, Tsai Li-Huei, Dobyns William, Ledbetter David, Hirotsune Shinji, Wynshaw-Boris Anthony (Jul. 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nat. Genet. (United States) 34 (3): 274–85. doi:10.1038/ng1169. ISSN 1061-4036. PMID 12796778. 
5. ^ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986. 
6. ^ Ozeki, Yuji; Tomoda Toshifumi, Kleiderlein John, Kamiya Atsushi, Bord Lyuda, Fujii Kumiko, Okawa Masako, Yamada Naoto, Hatten Mary E, Snyder Solomon H, Ross Christopher A, Sawa Akira (Jan. 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (1): 289–94. doi:10.1073/pnas.0136913100. ISSN 0027-8424. PMC 140954. PMID 12506198. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140954. 

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267. 
• Feng Y, Olson EC, Stukenberg PT, et al. (2001). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.". Neuron 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ozeki Y, Tomoda T, Kleiderlein J, et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140954. 
• Yan X, Li F, Liang Y, et al. (2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.". Mol. Cell. Biol. 23 (4): 1239–50. doi:10.1128/MCB.23.4.1239-1250.2003. PMC 141156. PMID 12556484. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=141156. 
• Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180354. 
• Toyo-oka K, Shionoya A, Gambello MJ, et al. (2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.". Nat. Genet. 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778. 
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Brandon NJ, Handford EJ, Schurov I, et al. (2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.". Mol. Cell. Neurosci. 25 (1): 42–55. doi:10.1016/j.mcn.2003.09.009. PMID 14962739. 
• Liang Y, Yu W, Li Y, et al. (2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.". J. Cell Biol. 164 (4): 557–66. doi:10.1083/jcb.200308058. PMC 2171987. PMID 14970193. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171987. 
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Tarricone C, Perrina F, Monzani S, et al. (2005). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.". Neuron 44 (5): 809–21. doi:10.1016/j.neuron.2004.11.019. PMID 15572112. 
• Hayashi MA, Portaro FC, Bastos MF, et al. (2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1.". Proc. Natl. Acad. Sci. U.S.A. 102 (10): 3828–33. doi:10.1073/pnas.0500330102. PMC 553309. PMID 15728732. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553309. 
• Guerreiro JR, Winnischofer SM, Bastos MF, et al. (2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation.". Biochim. Biophys. Acta 1730 (1): 77–84. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.