- YAP1
Yes-associated protein 1, 65kDa, also known as YAP1, is a human
gene .cite web | title = Entrez Gene: YAP1 Yes-associated protein 1, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10413| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.cite web | title = Entrez Gene: YAP1 Yes-associated protein 1, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10413| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Sudol M, Chen HI, Bougeret C, "et al." |title=Characterization of a novel protein-binding module--the WW domain. |journal=FEBS Lett. |volume=369 |issue= 1 |pages= 67–71 |year= 1995 |pmid= 7641887 |doi=
*cite journal | author=Chen HI, Sudol M |title=The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7819–23 |year= 1995 |pmid= 7644498 |doi=
*cite journal | author=Sudol M, Bork P, Einbond A, "et al." |title=Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14733–41 |year= 1995 |pmid= 7782338 |doi=
*cite journal | author=Chen HI, Einbond A, Kwak SJ, "et al." |title=Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17070–7 |year= 1997 |pmid= 9202023 |doi=
*cite journal | author=Gavva NR, Gavva R, Ermekova K, "et al." |title=Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24105–8 |year= 1997 |pmid= 9305852 |doi=
*cite journal | author=Yagi R, Chen LF, Shigesada K, "et al." |title=A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. |journal=EMBO J. |volume=18 |issue= 9 |pages= 2551–62 |year= 1999 |pmid= 10228168 |doi= 10.1093/emboj/18.9.2551
*cite journal | author=Mohler PJ, Kreda SM, Boucher RC, "et al." |title=Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 879–90 |year= 1999 |pmid= 10562288 |doi=
*cite journal | author=Espanel X, Sudol M |title=Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14514–23 |year= 2001 |pmid= 11278422 |doi= 10.1074/jbc.M008568200
*cite journal | author=Strano S, Munarriz E, Rossi M, "et al." |title=Physical interaction with Yes-associated protein enhances p73 transcriptional activity. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15164–73 |year= 2001 |pmid= 11278685 |doi= 10.1074/jbc.M010484200
*cite journal | author=Vassilev A, Kaneko KJ, Shu H, "et al." |title=TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. |journal=Genes Dev. |volume=15 |issue= 10 |pages= 1229–41 |year= 2001 |pmid= 11358867 |doi= 10.1101/gad.888601
*cite journal | author=Pires JR, Taha-Nejad F, Toepert F, "et al." |title=Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope. |journal=J. Mol. Biol. |volume=314 |issue= 5 |pages= 1147–56 |year= 2002 |pmid= 11743730 |doi= 10.1006/jmbi.2000.5199
*cite journal | author=Ferrigno O, Lallemand F, Verrecchia F, "et al." |title=Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. |journal=Oncogene |volume=21 |issue= 32 |pages= 4879–84 |year= 2002 |pmid= 12118366 |doi= 10.1038/sj.onc.1205623
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Basu S, Totty NF, Irwin MS, "et al." |title=Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 11–23 |year= 2003 |pmid= 12535517 |doi=
*cite journal | author=Komuro A, Nagai M, Navin NE, Sudol M |title=WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33334–41 |year= 2003 |pmid= 12807903 |doi= 10.1074/jbc.M305597200
*cite journal | author=Omerovic J, Puggioni EM, Napoletano S, "et al." |title=Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. |journal=Exp. Cell Res. |volume=294 |issue= 2 |pages= 469–79 |year= 2004 |pmid= 15023535 |doi= 10.1016/j.yexcr.2003.12.002
*cite journal | author=Howell M, Borchers C, Milgram SL |title=Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26300–6 |year= 2004 |pmid= 15096513 |doi= 10.1074/jbc.M401070200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Levy D, Adamovich Y, Reuven N, Shaul Y.|title=The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. |journal= Cell Death and Differentiation.|volume=14 |issue= 4 |pages= 743–51 |year= 2007 |pmid= 17110958 |doi= 10.1038/sj.cdd.4402063
*cite journal | author=Levy D, Adamovich Y, Reuven N, Shaul Y.|title=Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage |journal= Molecular Cell.|volume=29 |issue= 3 |pages= 350–61 |year= 2008|pmid= 18280240 |doi= 10.1016/j.molcel.2007.12.022PBB_Controls
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