STUB1

STUB1

STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene.cite web | title = Entrez Gene: STUB1 STIP1 homology and U-box containing protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10273| accessdate = ] cite journal | author = Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C | title = Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions | journal = Mol. Cell. Biol. | volume = 19 | issue = 6 | pages = 4535–45 | year = 1999 | month = June | pmid = 10330192 | pmc = 104411 | url = http://mcb.asm.org/cgi/content/abstract/19/6/4535 | issn = ]

Function

The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation.cite journal | author = Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C | title = CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 42938–44 | year = 2001 | month = November | pmid = 11557750 | doi = 10.1074/jbc.M101968200 | url = | issn = ] CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery.cite journal | author = Qian SB, McDonough H, Boellmann F, Cyr DM, Patterson C | title = CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 | journal = Nature | volume = 440 | issue = 7083 | pages = 551–5 | year = 2006 | month = March | pmid = 16554822 | doi = 10.1038/nature04600 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Patterson C |title=A new gun in town: the U box is a ubiquitin ligase domain. |journal=Sci. STKE |volume=2002 |issue= 116 |pages= PE4 |year= 2002 |pmid= 11805346 |doi= 10.1126/stke.2002.116.pe4
*cite journal | author=Scanlan MJ, Chen YT, Williamson B, "et al." |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652–8 |year= 1998 |pmid= 9610721 |doi=
*cite journal | author=Ballinger CA, Connell P, Wu Y, "et al." |title=Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4535–45 |year= 1999 |pmid= 10330192 |doi=
*cite journal | author=Connell P, Ballinger CA, Jiang J, "et al." |title=The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 93–6 |year= 2001 |pmid= 11146632 |doi= 10.1038/35050618
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Jiang J, Ballinger CA, Wu Y, "et al." |title=CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42938–44 |year= 2001 |pmid= 11557750 |doi= 10.1074/jbc.M101968200
*cite journal | author=Demand J, Alberti S, Patterson C, Höhfeld J |title=Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. |journal=Curr. Biol. |volume=11 |issue= 20 |pages= 1569–77 |year= 2002 |pmid= 11676916 |doi=
*cite journal | author=Imai Y, Soda M, Hatakeyama S, "et al." |title=CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. |journal=Mol. Cell |volume=10 |issue= 1 |pages= 55–67 |year= 2002 |pmid= 12150907 |doi=
*cite journal | author=Krackhardt AM, Witzens M, Harig S, "et al." |title=Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. |journal=Blood |volume=100 |issue= 6 |pages= 2123–31 |year= 2002 |pmid= 12200376 |doi= 10.1182/blood-2002-02-0513
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cardozo CP, Michaud C, Ost MC, "et al." |title=C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. |journal=Arch. Biochem. Biophys. |volume=410 |issue= 1 |pages= 134–40 |year= 2003 |pmid= 12559985 |doi=
*cite journal | author=Zhou P, Fernandes N, Dodge IL, "et al." |title=ErbB2 degradation mediated by the co-chaperone protein CHIP. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13829–37 |year= 2003 |pmid= 12574167 |doi= 10.1074/jbc.M209640200
*cite journal | author=Shimura H, Schwartz D, Gygi SP, Kosik KS |title=CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4869–76 |year= 2004 |pmid= 14612456 |doi= 10.1074/jbc.M305838200
*cite journal | author=Li L, Xin H, Xu X, "et al." |title=CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 856–64 |year= 2004 |pmid= 14701756 |doi=
*cite journal | author=Petrucelli L, Dickson D, Kehoe K, "et al." |title=CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. |journal=Hum. Mol. Genet. |volume=13 |issue= 7 |pages= 703–14 |year= 2004 |pmid= 14962978 |doi= 10.1093/hmg/ddh083
*cite journal | author=Galigniana MD, Harrell JM, Housley PR, "et al." |title=Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. |journal=Brain Res. Mol. Brain Res. |volume=123 |issue= 1-2 |pages= 27–36 |year= 2004 |pmid= 15046863 |doi= 10.1016/j.molbrainres.2003.12.015
*cite journal | author=He B, Bai S, Hnat AT, "et al." |title=An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP). |journal=J. Biol. Chem. |volume=279 |issue= 29 |pages= 30643–53 |year= 2004 |pmid= 15107424 |doi= 10.1074/jbc.M403117200
*cite journal | author=Alberti S, Böhse K, Arndt V, "et al." |title=The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. |journal=Mol. Biol. Cell |volume=15 |issue= 9 |pages= 4003–10 |year= 2005 |pmid= 15215316 |doi= 10.1091/mbc.E04-04-0293
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

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