Kynurenine-oxoglutarate transaminase

In enzymology, a kynurenine-oxoglutarate transaminase (EC number|2.6.1.7) is an enzyme that catalyzes the chemical reaction

:L-kynurenine + 2-oxoglutarate $ightleftharpoons$ 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate

Thus, the two substrates of this enzyme are L-kynurenine and 2-oxoglutarate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:2-oxoglutarate aminotransferase. Other names in common use include kynurenine transaminase (cyclizing), kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, and L-kynurenine aminotransferase. This enzyme participates in tryptophan metabolism. It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1X0M, PDB link|1YIY, 1W7L, and PDB link|1YIZ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-38-0."

Gene Ontology (GO) codes