Ubiquitin-protein ligase

In enzymology, an ubiquitin-protein ligase (EC number|6.3.2.19) is an enzyme that catalyzes the chemical reaction

:ATP + ubiquitin + protein lysine $ightleftharpoons$ AMP + diphosphate + protein N-ubiquityllysine

The 3 substrates of this enzyme are ATP, ubiquitin, and protein lysine, whereas its 3 products are AMP, diphosphate, and protein N-ubiquityllysine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is ubiquitin:protein-lysine N-ligase (AMP-forming). This enzyme is also called ubiquitin-activating enzyme. This enzyme participates in 3 metabolic pathways: ubiquitin mediated proteolysis, parkinson's disease, and huntington's disease.

tructural studies

As of late 2007, 75 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A3S, PDB link|1AYZ, PDB link|1C4Z, PDB link|1FBV, PDB link|1FXT, PDB link|1FZY, PDB link|1I7K, PDB link|1IYF, PDB link|1J7D, PDB link|1JAS, PDB link|1JAT, PDB link|1JBB, PDB link|1KPS, PDB link|1PZV, PDB link|1Q34, PDB link|1QCQ, PDB link|1TTE, PDB link|1U9A, PDB link|1U9B, PDB link|1UMH, PDB link|1UMI, PDB link|1UR6, PDB link|1W4U, PDB link|1WD2, PDB link|1WZV, PDB link|1WZW, PDB link|1X23, PDB link|1XR9, PDB link|1Y6L, PDB link|1Y8X, PDB link|1YH6, PDB link|1YLA, PDB link|1YRV, PDB link|1Z2U, PDB link|1Z3D, PDB link|1Z5S, PDB link|1Z6U, PDB link|1ZDN, PDB link|1ZUO, PDB link|2A4D, PDB link|2A7L, PDB link|2AAK, PDB link|2AWF, PDB link|2AYV, PDB link|2BEP, PDB link|2BF8, PDB link|2C4O, PDB link|2C4P, PDB link|2CLW, PDB link|2CYX, PDB link|2E2C, PDB link|2EKE, PDB link|2ESK, PDB link|2ESO, PDB link|2ESP, PDB link|2ESQ, PDB link|2F4W, PDB link|2FO3, PDB link|2FUH, PDB link|2GJD, PDB link|2GMI, PDB link|2GRN, PDB link|2GRO, PDB link|2GRP, PDB link|2GRQ, PDB link|2GRR, PDB link|2H2Y, PDB link|2O25, PDB link|2OB4, PDB link|2OGB, PDB link|2ONU, PDB link|2UCZ, PDB link|2UYZ, PDB link|2Z6O, and PDB link|2Z6P.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|74812-49-0."

Gene Ontology (GO) codes