Cyclamate sulfohydrolase

Cyclamate sulfohydrolase
cyclamate sulfohydrolase
Identifiers
EC number 3.10.1.2
CAS number 52228-00-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cyclamate sulfohydrolase (EC 3.10.1.2) is an enzyme that catalyzes the chemical reaction

cyclohexylsulfamate + H2O \rightleftharpoons cyclohexylamine + sulfate

Thus, the two substrates of this enzyme are cyclohexylsulfamate and H2O, whereas its two products are cyclohexylamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is cyclohexylsulfamate sulfohydrolase. Other names in common use include cyclamate sulfamatase, cyclamate sulfamidase, and cyclohexylsulfamate sulfamidase. This enzyme participates in caprolactam degradation.

References

  • Nimura T, Tokieda T, Yamaha T (Tokyo). "Partial purification and some properties of cyclamate sulfamatase". J. Biochem. (2): 407–17. PMID 4209783.