- 2-hydroxymuconate-semialdehyde hydrolase
In
enzymology , a 2-hydroxymuconate-semialdehyde hydrolase (EC number|3.7.1.9) is anenzyme that catalyzes thechemical reaction :2-hydroxymuconate semialdehyde + H2O formate + 2-oxopent-4-enoate
Thus, the two substrates of this enzyme are
2-hydroxymuconate semialdehyde and H2O, whereas its two products areformate and2-oxopent-4-enoate .This enzyme belongs to the family of
hydrolase s, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2-hydroxymuconate-semialdehyde formylhydrolase. Other names in common use include 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, 2-hydroxymuconic semialdehyde hydrolase, HMSH, and HOD hydrolase. This enzyme participates in 5 metabolic pathways:benzoate degradation via hydroxylation ,toluene and xylene degradation ,1,4-dichlorobenzene degradation ,carbazole degradation , andstyrene degradation .tructural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IUN, PDB link|1IUO, PDB link|1IUP, PDB link|1UK6, PDB link|1UK7, PDB link|1UK8, PDB link|1UK9, PDB link|1UKA, PDB link|1UKB, and PDB link|2D0D.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|54004-61-4."Gene Ontology (GO) codes
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