PPP2CB

Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, also known as PPP2CB, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.cite web | title = Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5516| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–35 |year= 2000 |pmid= 11007961 |doi=
*cite journal | author=Goedert M, Cohen ES, Jakes R, Cohen P |title=p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected] |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 95–9 |year= 1992 |pmid= 1330687 |doi=
*cite journal | author=Khew-Goodall Y, Mayer RE, Maurer F, "et al." |title=Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. |journal=Biochemistry |volume=30 |issue= 1 |pages= 89–97 |year= 1991 |pmid= 1846293 |doi=
*cite journal | author=Pallas DC, Shahrik LK, Martin BL, "et al." |title=Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. |journal=Cell |volume=60 |issue= 1 |pages= 167–76 |year= 1990 |pmid= 2153055 |doi=
*cite journal | author=Virshup DM, Kauffman MG, Kelly TJ |title=Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3891–8 |year= 1990 |pmid= 2555176 |doi=
*cite journal | author=Arino J, Woon CW, Brautigan DL, "et al." |title=Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 12 |pages= 4252–6 |year= 1988 |pmid= 2837763 |doi=
*cite journal | author=Hemmings BA, Wernet W, Mayer R, "et al." |title=The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. |journal=Nucleic Acids Res. |volume=16 |issue= 23 |pages= 11366 |year= 1989 |pmid= 2849765 |doi=
*cite journal | author=Favre B, Zolnierowicz S, Turowski P, Hemmings BA |title=The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. |journal=J. Biol. Chem. |volume=269 |issue= 23 |pages= 16311–7 |year= 1994 |pmid= 8206937 |doi=
*cite journal | author=Jones TA, Barker HM, da Cruz e Silva EF, "et al." |title=Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 1 |pages= 35–41 |year= 1993 |pmid= 8383590 |doi=
*cite journal | author=Keranen LM, Dutil EM, Newton AC |title=Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. |journal=Curr. Biol. |volume=5 |issue= 12 |pages= 1394–1403 |year= 1997 |pmid= 8749392 |doi=
*cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, "et al." |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=
*cite journal | author=Nagase T, Murakami T, Nozaki H, "et al." |title=Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit. |journal=J. Biochem. |volume=122 |issue= 1 |pages= 178–87 |year= 1997 |pmid= 9276686 |doi=
*cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432–43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873
*cite journal | author=Hsu W, Zeng L, Costantini F |title=Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3439–45 |year= 1999 |pmid= 9920888 |doi=
*cite journal | author=Ogris E, Du X, Nelson KC, "et al." |title=A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14382–91 |year= 1999 |pmid= 10318862 |doi=
*cite journal | author=De Baere I, Derua R, Janssens V, "et al." |title=Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. |journal=Biochemistry |volume=38 |issue= 50 |pages= 16539–47 |year= 2000 |pmid= 10600115 |doi=
*cite journal | author=Götz J, Probst A, Mistl C, "et al." |title=Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development. |journal=Mech. Dev. |volume=93 |issue= 1-2 |pages= 83–93 |year= 2000 |pmid= 10781942 |doi=
*cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956
*cite journal | author=Lüss H, Klein-Wiele O, Bokník P, "et al." |title=Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart. |journal=J. Mol. Cell. Cardiol. |volume=32 |issue= 12 |pages= 2349–59 |year= 2001 |pmid= 11113010 |doi= 10.1006/jmcc.2000.1265

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