CRYAB

CRYAB
Crystallin, alpha B

Rendering based on PDB 2KLR.
Identifiers
Symbols CRYAB; CRYA2; CTPP2; HSPB5
External IDs OMIM123590 MGI88516 HomoloGene68209 GeneCards: CRYAB Gene
RNA expression pattern
PBB GE CRYAB 209283 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1410 12955
Ensembl ENSG00000109846 ENSMUSG00000032060
UniProt P02511 Q52L78
RefSeq (mRNA) NM_001885.1 NM_009964.2
RefSeq (protein) NP_001876.1 NP_034094.1
Location (UCSC) Chr 11:
111.78 – 111.79 Mb
Chr 9:
50.56 – 50.56 Mb
PubMed search [1] [2]

Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene.[1]

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups.

Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone.

These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.[2]

Contents

Interactions

CRYAB has been shown to interact with CRYBB2,[3] Hsp27,[4][3] HSPB2,[5] CRYGC,[3] PSMA3[6] and CRYAA.[3]

See also

References

  1. ^ Jeanpierre C, Austruy E, Delattre O, Jones C, Junien C (Mar 1993). "Subregional physical mapping of an alpha B-crystallin sequence and of a new expressed sequence D11S877E to human 11q". Mamm Genome 4 (2): 104–8. doi:10.1007/BF00290434. PMID 8431633. 
  2. ^ "Entrez Gene: CRYAB crystallin, alpha B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1410. 
  3. ^ a b c d Fu, Ling; Liang Jack J-N (Feb. 2002). "Detection of protein-protein interactions among lens crystallins in a mammalian two-hybrid system assay". J. Biol. Chem. (United States) 277 (6): 4255–60. doi:10.1074/jbc.M110027200. ISSN 0021-9258. PMID 11700327. 
  4. ^ Kato, K; Shinohara H, Goto S, Inaguma Y, Morishita R, Asano T (Apr. 1992). "Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle". J. Biol. Chem. (UNITED STATES) 267 (11): 7718–25. ISSN 0021-9258. PMID 1560006. 
  5. ^ Sugiyama, Y; Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye M M, Tsui S K, Yoshida S, Ohno S (Jan. 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. (UNITED STATES) 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. ISSN 0021-9258. PMID 10625651. 
  6. ^ Boelens, W C; Croes Y, de Jong W W (Jan. 2001). "Interaction between alphaB-crystallin and the human 20S proteasomal subunit C8/alpha7". Biochim. Biophys. Acta (Netherlands) 1544 (1–2): 311–9. ISSN 0006-3002. PMID 11341940. 

External links

Further reading

  • Derham BK, Harding JJ (1999). "Alpha-crystallin as a molecular chaperone". Progress in retinal and eye research 18 (4): 463–509. doi:10.1016/S1350-9462(98)00030-5. PMID 10217480. 
  • Calinisan V, Gravem D, Chen RP et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium". Front. Biosci. 11: 1646–66. doi:10.2741/1911. PMID 16368544. 




Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Kleine Hitzeschockproteine — (Hsp20) (engl. small heat shock proteins, kurz sHsps) sind Proteine mit Molekülmassen von 12 bis 42 kDa, die in allen Lebewesen vorkommen. Sie gehören zur Familie der Hitzeschockproteine, die bei Hitze und anderen zellulären… …   Deutsch Wikipedia

  • Alpha crystallin — protein Name= crystallin, alpha A caption= width= HGNCid = 2388 Symbol = CRYAA AltSymbols=CRYA1 EntrezGene=1409 OMIM=123580 RefSeq=NM 000394 UniProt=P02489 PDB= ECnumber= Chromosome=21 Arm=q Band=22.3 LocusSupplementaryData=protein… …   Wikipedia

  • Chromosome 11 Humain — Le chromosome 11 est un des 24 chromosomes humains. C est l un des 22 autosomes. Sommaire 1 Caractéristiques du chromosome 11 2 Anom …   Wikipédia en Français

  • Chromosome 11 humain — Le chromosome 11 est un des 24 chromosomes humains. C est l un des 22 autosomes. Sommaire 1 Caractéristiques du chromosome 11 2 Anomalies chromosomiques décrites au …   Wikipédia en Français

  • Myopathie Avec Surcharge En Desmine — Autre nom {{{Autre nom}}} Référence MIM …   Wikipédia en Français

  • Myopathie avec surcharge en desmine — Référence MIM 601419 Transmission Dominante Chromosome 5q31 11q22.3 q23.1 2q35 Gène TTID CRYAB DES Mutation …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”