Dimethylmalate dehydrogenase

dimethylmalate dehydrogenase
Identifiers
EC number	1.1.1.84
CAS number	37250-21-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dimethylmalate dehydrogenase (EC 1.1.1.84) is an enzyme that catalyzes the chemical reaction

(R)-3,3-dimethylmalate + NAD⁺ $\rightleftharpoons$ 3-methyl-2-oxobutanoate + CO₂ + NADH

Thus, the two substrates of this enzyme are (R)-3,3-dimethylmalate and NAD⁺, whereas its 3 products are 3-methyl-2-oxobutanoate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD⁺ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: NH₃, manganese, cobalt, potassium, and NH₄⁺.

References

• Magee PT, Snell EE (1966). "The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate". Biochemistry. 5 (2): 409–16. doi:10.1021/bi00866a004. PMID 4287371. 

This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: EC 1.1.1 stubs EC 1.1.1 NADH-dependent enzymes Manganese enzymes Cobalt enzymes Potassium enzymes NH4+ enzymes Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Diiodophenylpyruvate reductase Nothofagus obliqua Look at other dictionaries: (R)-dehydropantoate dehydrogenase — In enzymology, a (R) dehydropantoate dehydrogenase (EC number|1.2.1.33) is an enzyme that catalyzes the chemical reaction:(R) 4 dehydropantoate + NAD+ + H2O ightleftharpoons (R) 3,3 dimethylmalate + NADH + 2 H+The 3 substrates of this enzyme are… …   Wikipedia List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”