D-arabinitol 2-dehydrogenase

D-arabinitol 2-dehydrogenase
Identifiers
EC number	1.1.1.250
CAS number	336883-93-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a D-arabinitol 2-dehydrogenase (EC 1.1.1.250) is an enzyme that catalyzes the chemical reaction

D-arabinitol + NAD⁺ $\rightleftharpoons$ D-ribulose + NADH + H⁺

Thus, the two substrates of this enzyme are D-arabinitol and NAD⁺, whereas its 3 products are D-ribulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming). This enzyme is also called D-arabinitol 2-dehydrogenase (ribulose-forming).

References

• Wong B, Murray JS, Castellanos M, Croen KD (1993). "D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase". J. Bacteriol. 175 (19): 6314–20. PMC 206728. PMID 8407803. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=206728. 
• Quong MW, Miyada CG, Switchenko AC, Goodman TC (1993). "Identification, purification, and characterization of a D-arabinitol-specific dehydrogenase from Candida tropicalis". Biochem. Biophys. Res. Commun. 196 (3): 1323–9. doi:10.1006/bbrc.1993.2397. PMID 8250887. 

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