Pterin

Pterin

Chembox new
ImageFile = pterin structure.png ImageSize = 200px
IUPACName = 2-amino-1H-pteridin-4-one
OtherNames =Pteridoxamine
Pterine
4-Oxopterin
2-Amino-4-pteridone
2-Amino-4-hydroxypteridine
2-Amino-4-oxopteridine
2-aminopteridin-4-ol
2-Amino-4-pteridinol
Section1 = Chembox Identifiers
CASNo = 2236-60-4
PubChem = 73000
SMILES = C1=CN=C2C(=N1)C(=O)N=C(N2)N

Section2 = Chembox Properties
C=6|H=5|N=5|O=1
MolarMass = 163.137
Appearance =
Density =
MeltingPt =
BoilingPt =
Solubility =

Section3 = Chembox Hazards
MainHazards =
FlashPt =
Autoignition =

Pterin is a heterocyclic compound composed of a pyrazine ring and a pyrimidine ring (a pteridine ring system); the pyrimidine ring has a carbonyl oxygen and an amino group. Several tautomers of pterin exist and are shown below. As a group, "pterins" are compounds that are derivatives of 2-amino-4-oxopteridine, with additional functional groups attached to the pyrazine ring.

Pterins were first discovered in the pigments of butterfly wings (hence the origin of their name, from the Greek "pteron", wing) and perform many roles in coloration in the biological world. Pterins also function as cofactors in enzyme catalysis.

Folates are “conjugated” pteridines which contain para-aminobenzoic acid and glutamates at the 6 position on the pteridine ring. They are critical compounds in a large number of biological group transfer reactions. These folate-dependent biosynthetic reactions include transfer of methyl groups to homocystine in the S-adenosyl methionine cycle, and transfer of formyl groups to methionine to form "N"-formylmethionine in initiator tRNAs.

Tautomers of pterin

Biosynthesis

The biosynthesis of pterins begins with the molecule guanosine triphosphate (GTP); the enzyme which controls the conversion of GTP to pterin, GTP cyclohydrolase I, is found in both prokaryotes and eukaryotes.

Other pterins

Pterin can exist in many different forms in nature depending on its function. Tetrahydrobiopterin, the major unconjugated pteridine in vertebrates, is a co-factor in the hydroxylation of aromatic compounds and synthesis of nitric oxide. Molybdopterin is a substituted pteridine that binds molybdenum to give redox enzymes involved in biological hydroxylations, reduction of nitrate, and respiratory oxidation. Tetrahydromethanopterin is used in methanogenic organisms. Cyanopterin is a glycosylated version of pteridine of unknown function in cyanobacteria.

ee also

*Pteridine
*Tetrahydrobiopterin
*Molybdopterin
*Cyanopterin
*Tetrahydromethanopterin
*Folic acid

External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Pterin — Strukturformel Allgemeines Name Pterin Andere Namen 2 …   Deutsch Wikipedia

  • Pterin deaminase — In enzymology, a pterin deaminase (EC number|3.5.4.11) is an enzyme that catalyzes the chemical reaction:2 amino 4 hydroxypteridine + H2O ightleftharpoons 2,4 dihydroxypteridine + NH3Thus, the two substrates of this enzyme are 2 amino 4… …   Wikipedia

  • pterin — noun Etymology: International Scientific Vocabulary pter (from Greek pteron wing) + 1 in; from its being a factor in the pigments of butterfly wings Date: 1934 any of various compounds that contain the bicyclic ring system characteristic of… …   New Collegiate Dictionary

  • pterin — noun A chemical compound responsible for some of the colouring in nature. It is also a component of folic acid …   Wiktionary

  • pterin — Term loosely used for any of the compounds containing pteridine; specifically, 2 amino 4 hydroxypteridine. Some pteridines ( e.g., xanthopterin, leucopterin) still retain the p. root. p. deaminase an aminohydrolase catalyzing hydrolytic… …   Medical dictionary

  • Pterin — Pte|rin [↑ Pter u. ↑ in (3)]: das; s, e: ↑ Pteridin …   Universal-Lexikon

  • pterin — pter·in …   English syllables

  • pterin — ˈterə̇n noun ( s) Etymology: International Scientific Vocabulary pter + in; originally formed in German; from its being a factor in the pigments of butterfly wings : a compound containing the pteridine ring system …   Useful english dictionary

  • pterin-4α-carbinolamine dehydratase — (PCD) pter·in 4α car·bin·ol·amine de·hy·dra·tase (PCD) (terґin kahr″bin olґə mēn de hiґdrə tās) 4a hydroxytetrahydrobiopterin dehydratase …   Medical dictionary

  • PCBD1 — Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha PDB rendering based on 1dch …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”