- Purine riboswitch
Purine riboswitches are
RNA structures that regulateprotein biosynthesis in response topurine scite journal | last = Mandal | first = M | coauthors = Boese B, Barrick JE, Winkler WC, Breaker RR | year = 2003 | title = Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria | journal = Cell | volume = 113 | pages = 577–586 | pmid = 12787499 | doi = 10.1016/S0092-8674(03)00391-X] . In general,riboswitches are metabolite-binding domains within certainmessenger RNA s that act as precision sensors for their corresponding targets. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression. [cite journal | last = Batey | first = RT | coauthors = Gilbert SD, Montange RK | year = 2004 | title = Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine | journal = Nature. | volume = 432 | pages = 411–415 | pmid = 15549109 | doi = 10.1038/nature03037]Purine
riboswitch es are a class of riboswitches that selectively recognisesguanine and become saturated at concentrations as low as 5 nM. In "Bacillus subtilis ", this mRNA motif is located on at least five separate transcriptional units that together encode 17 genes that are mostly involved in purine transport and purine nucleotide synthesis. As some members of this family are also specific foradenine [cite journal | last = Mandal | first = M | coauthors = Breaker RR | year = 2004 | title = Adenine riboswitches and gene activation by disruption of a transcription terminator | journal = Nat Struct Mol Biol | volume = 11 | pages = 29–35 | pmid = 14718920 | doi = 10.1038/nsmb710] ordeoxyguanosine cite journal |author=Kim JN, Roth A, Breaker RR |title=Guanine riboswitch variants from Mesoplasma florum selectively recognize 2'-deoxyguanosine |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue=41 |pages=16092–7 |year=2007 |pmid=17911257 |doi=10.1073/pnas.0705884104] , this family are termed purine riboswitches.References
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