Interferon gamma 5' UTR regulatory element

Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma. [cite journal | last = Ben-Asouli | first = Y | coauthors = Banai Y, Pel-Or Y, Shir A, Kaempfer R | year = 2002 | title = Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR | journal = Cell | volume = 108 | pages = 221–232 | pmid = 11832212 | doi = 10.1016/S0092-8674(02)00616-5]

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