Dihydropteroate

Dihydropteroate
IUPAC name 4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoic acid
Identifiers
CAS number	2134-76-1 N
PubChem	170
ChemSpider	165 Y
KEGG	C00921 N
ChEBI	CHEBI:4581 Y
Beilstein Reference	1226443
Jmol-3D images	Image 1 Image 2
SMILES C1C(=NC2=C(N1)NC(=NC2=O)N) CNC3=CC=C(C=C3)C(=O)O O=C(O)c1ccc(cc1)NCC/2=N/C=3C(=O)\N=C(/NC=3NC\2)N
InChI InChI=1S/C14H14N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,16H,5-6H2,(H,22,23)(H4,15,17,19,20,21) Y Key: WBFYVDCHGVNRBH-UHFFFAOYSA-N Y
Properties
Molecular formula	C14H14N6O3
Molar mass	314.3 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dihydropteroate is a pterin created from para-aminobenzoic acid (PABA) by the enzyme dihydropteroate synthetase. It is an important intermediate in folate synthesis.

Tetrahydrofolate synthesis pathway

Bacteriostatic agents, such as sulfonamides, target dihydropteroate synthetase. The effect of dihydropteroate synthetase inhibition is comparable to that of dihydrofolate reductase inhibition by trimethoprim, another bacteriostatic agent. Together these two drugs - trimethoprim-sulfamethoxazole [TMP-SMX] - are commonly used to treat recurrent urinary tract, Shigella, Salmonella, and Pneumocystis jivoreci infections.

See also

• Dihydrofolic acid

This article about an organic compound is a stub. You can help Wikipedia by expanding it.v · Categories: Benzoic acids Organic compound stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Sanghania Philippe Servaty Look at other dictionaries: dihydropteroate — noun A pterin created from para aminobenzoic acid by the enzyme dihydropteroate synthetase, an important intermediate in folate synthesis …   Wiktionary Dihydropteroate synthase — Tetrahydrofolate synthesis pathway Identifiers EC number …   Wikipedia Dihydropteroate synthetase — is an enzyme classified under EC number|2.5.1.15. It produces dihydropteroate in bacteria, but does not function in humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.It acts upon 4… …   Wikipedia Dihydropteroate synthase inhibitor — A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides. Tetrahydrofolate synthesis pathway In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme …   Wikipedia Dihydrofolate synthase — Identifiers EC number 6.3.2.12 CAS number 37318 62 0 …   Wikipedia Sulfanilamide — Général Nom IUPAC 4 aminobenzenesulfonamide Synonymes …   Wikipédia en Français Sulfonamide (medicine) — There are several sulfonamide based groups of drugs. The original antibacterial sulfonamides (sometimes called simply sulfa drugs) are synthetic antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of… …   Wikipedia Dapsone — Systematic (IUPAC) name 4 [(4 aminobenzene)sulfonyl]aniline …   Wikipedia Tetrahydrofolic acid — Chembox new ImageFile = Tetrahydrofolic acid.svg ImageSize = 250px IUPACName = OtherNames = Section1 = Chembox Identifiers CASNo = 29347 89 5 PubChem = 1129 SMILES = MeSHName = 5,6,7,8 tetrahydrofolic+acid Section2 = Chembox Properties Formula =… …   Wikipedia List of antibiotics — Following is the list of antibiotics, sorted by class. The highest division is between bactericidal antibiotics and bacteriostatic antibiotics. Bactericidals kill bacteria directly where bacteriostatics prevent them from dividing. However, these… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”