SNAP-25

SNAP-25

SNAP-25 (synaptosome-associated protein of 25,000 daltons) is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP-25 is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP-25 inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically cite journal
author = Hodel A
title = SNAP-25
journal = The International Journal of Biochemistry & Cell Biology
volume = 30
issue = 10
pages = 1069–1073
year = 1998
doi = 10.1016/S1357-2725(98)00079-X
] and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion cite journal
author = Chapman ER
title = [http://www.physiology.wisc.edu/chapman/papers/naturereview.pdf Synaptotagmin: A Ca2+ sensor that triggers exocytosis?]
journal = Nature Reviews Molecular Cell Biology
volume = 3
pages = 498–508
year = 2002
] . In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses cite journal
author = Pozzi D, Verderio C, Patti L, Grumelli C, Inverardi F, Frassoni C, Bonanno G, Matteoli M
title = [http://dx.doi.org/10.1016/S0896-6273(04)00077-7 SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization]
journal = Neuron
volume = 41
issue = 4
pages = 599–610
year = 2004
doi = 10.1016/S0896-6273(04)00077-7
] .

Consistent with the regulation of synaptic Ca2+ responsiveness, heterozygous deletion of the SNAP-25 gene in mice results in a hyperactive phenotype similar to attention deficit hyperactivity disorder (ADHD). In heterozygous mice, a decrease in hyperactivity is observed with dextroamphetamine (or Dexedrine), an active ingredient in the ADHD drug Adderall. Homozygous deletions of the SNAP-25 gene are lethal. Subsequent studies have suggested that at least some of the SNAP-25 gene mutations in humans might predispose to ADHD cite journal
author = Brophy K, Hawi Z, Kirley A, Fitzgerald M, Gill M
title = Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population
journal = Molecular Psychiatry
volume = 7
issue = 8
pages = 913–917
year = 2002
doi = 10.1038/sj.mp.4001092
] cite journal
author = Mill J, Curran S, Kent L, Gould A, Huckett L, Richards S, Taylor E, Asherson P
title = Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder
journal = American Journal of Medical Genetics
volume = 114
issue = 3
pages = 269–271
year = 2002
doi = 10.1002/ajmg.10253
] .

Botulinum toxins A, C and E cleave SNAP-25 cite journal
author = Aoki KR, Guyer B
title = Botulinum toxin type A and other botulinum toxin serotypes: a comparative review of biochemical and pharmacological actions
journal = European Journal of Neurology
volume = 8
pages = 21–29
year = 2001
doi = 10.1046/j.1468-1331.2001.00035.x
] leading to paralysis in clinically developed botulism.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hanson PI, Otto H, Barton N, Jahn R |title=The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. |journal=J. Biol. Chem. |volume=270 |issue= 28 |pages= 16955–61 |year= 1995 |pmid= 7622514 |doi=
*cite journal | author=Hata Y, Südhof TC |title=A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13022–8 |year= 1995 |pmid= 7768895 |doi=
*cite journal | author=Chapman ER, An S, Barton N, Jahn R |title=SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27427–32 |year= 1994 |pmid= 7961655 |doi=
*cite journal | author=Zhao N, Hashida H, Takahashi N, Sakaki Y |title=Cloning and sequence analysis of the human SNAP25 cDNA. |journal=Gene |volume=145 |issue= 2 |pages= 313–4 |year= 1994 |pmid= 8056350 |doi=
*cite journal | author=Bark IC, Wilson MC |title=Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25. |journal=Gene |volume=139 |issue= 2 |pages= 291–2 |year= 1994 |pmid= 8112622 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Maglott DR, Feldblyum TV, Durkin AS, Nierman WC |title=Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p). |journal=Mamm. Genome |volume=7 |issue= 5 |pages= 400–1 |year= 1996 |pmid= 8661740 |doi=
*cite journal | author=Ravichandran V, Chawla A, Roche PA |title=Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. |journal=J. Biol. Chem. |volume=271 |issue= 23 |pages= 13300–3 |year= 1996 |pmid= 8663154 |doi=
*cite journal | author=Rettig J, Sheng ZH, Kim DK, "et al." |title=Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7363–8 |year= 1996 |pmid= 8692999 |doi=
*cite journal | author=Jagadish MN, Fernandez CS, Hewish DR, "et al." |title=Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. |journal=Biochem. J. |volume=317 ( Pt 3) |issue= |pages= 945–54 |year= 1996 |pmid= 8760387 |doi=
*cite journal | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520–6 |year= 1997 |pmid= 8999968 |doi=
*cite journal | author=Araki S, Tamori Y, Kawanishi M, "et al." |title=Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 1 |pages= 257–62 |year= 1997 |pmid= 9168999 |doi= 10.1006/bbrc.1997.6560
*cite journal | author=Lane SR, Liu Y |title=Characterization of the palmitoylation domain of SNAP-25. |journal=J. Neurochem. |volume=69 |issue= 5 |pages= 1864–9 |year= 1997 |pmid= 9349529 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Okamoto M, Südhof TC |title=Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31459–64 |year= 1998 |pmid= 9395480 |doi=
*cite journal | author=Low SH, Roche PA, Anderson HA, "et al." |title=Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3422–30 |year= 1998 |pmid= 9452464 |doi=
*cite journal | author=Poirier MA, Hao JC, Malkus PN, "et al." |title=Protease resistance of syntaxin.SNAP-25.VAMP complexes. Implications for assembly and structure. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11370–7 |year= 1998 |pmid= 9556632 |doi=
*cite journal | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957–71 |year= 1998 |pmid= 9817754 |doi=
*cite journal | author=Gonelle-Gispert C, Halban PA, Niemann H, "et al." |title=SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion. |journal=Biochem. J. |volume=339 ( Pt 1) |issue= |pages= 159–65 |year= 1999 |pmid= 10085240 |doi=
*cite journal | author=Ilardi JM, Mochida S, Sheng ZH |title=Snapin: a SNARE-associated protein implicated in synaptic transmission. |journal=Nat. Neurosci. |volume=2 |issue= 2 |pages= 119–24 |year= 1999 |pmid= 10195194 |doi= 10.1038/5673

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Snap — may refer to any of the following: * Snap (fingers), snapping one s fingersScience/Technology/Engineering: * S Nitroso N acetylpenicillamine, a biochemical reagent * SNAP 25, in molecular biology, soluble n ethyl maleimide sensitive attachment… …   Wikipedia

  • snap — [snap] vi. snapped, snapping [< MDu or MLowG snappen, akin to Ger schnappen < Gmc base * snab ] 1. to bring the jaws together sharply; bite suddenly: often with at [a fish snaps at bait] 2. to snatch or grasp quickly or eagerly: with at [to …   English World dictionary

  • Snap — Snap, n. [Cf. D. snap a snatching. See {Snap}, v. t.] 1. A sudden breaking or rupture of any substance. [1913 Webster] 2. A sudden, eager bite; a sudden seizing, or effort to seize, as with the teeth. [1913 Webster] 3. A sudden, sharp motion or… …   The Collaborative International Dictionary of English

  • Snap-on — (NYSE|SNA) is a leading U.S. designer, manufacturer and marketer of tools and equipment to professional tool users. It was founded in 1920. Snap on is located in Kenosha, Wisconsin, and employs approximately 11,500 people worldwide. The company… …   Wikipedia

  • Snap! — est un groupe culte de la musique électronique des années 1990. Créé par les allemands Michael Münzing (alias Benito Benites) et Luca Anzilotti (alias John Virgo Garrett III) en 1989. Snap est surtout connu pour son titre Rhythm is a dancer,… …   Wikipédia en Français

  • Snap — Snap, v. t. [imp. & p. p. {Snapped}; p. pr. & vb. n. {Snapping}.] [LG. or D. snappen to snap up, to snatch; akin to G. schnappen, MHG. snaben, Dan. snappe, and to D. snavel beak, bill. Cf. {Neb}, {Snaffle}, n.] 1. To break at once; to break short …   The Collaborative International Dictionary of English

  • snap — [snæp] verb snapped PTandPPX snapping PRESPARTX snap up phrasal verb [transitive] 1. snap something → up to buy something immediately, especially because it is very cheap: • If you see a computer for under £400, you should snap it up …   Financial and business terms

  • Snap! — Datos generales Origen Alemania Información artística …   Wikipedia Español

  • snap to it — mainly spoken phrase used for telling someone to do something immediately Thesaurus: ways of telling someone to hurrysynonym Main entry: snap * * * snap to it informal : to start working harder or more quickly You ll have to snap to it if you… …   Useful english dictionary

  • snap — ► VERB (snapped, snapping) 1) break with a sharp cracking sound. 2) (of an animal) make a sudden audible bite. 3) open or close with a brisk movement or sharp sound. 4) (snap up) quickly secure (something that is in short supply). 5) sud …   English terms dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”