Median raphe nucleus

Median raphe nucleus
Brain: Median raphe nucleus
Latin nucleus raphes medianus, nucleus centralis superior
NeuroNames hier-557
NeuroLex ID birnlex_889

The median raphe nucleus (also referred to as superior central nucleus, here abbreviated to MRN) is composed of polygonal, fusiform and pyriform neurons and exists rostral to the nucleus raphe pontis.

One trait of the MRN is its inhibition by lysergic acid diethylamide and psilocin, two serotonin antagonist hallucinogens. The inactivation of the nucleus centralis superior via LSD produces a dose dependent inactivation in the MRN, but not in the raphe pallidus.

The free-moving cats, in which this was discovered, exhibited dose dependent behavioral changes when researched by Dr. Michael Trulson of the neurology department at Texas A&M University Medical School.[1].

See also

References

  1. ^ Trulson, M.E., Preussler DW and Trulson V.M. Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in free-moving cats. American Society for Pharmacology and Experimental Therapeutics Volume 228, Issue 1, pp. 94-102, 1 January 1984
v · d · eHuman brain, rhombencephalon, metencephalon: pons (TA A14.1.05.101–604, GA 9.785)
Dorsal/
(tegmentum)
Surface
White: Sensory/ascending
White: Motor/descending
Other grey
Ventral/
(base)
White: Motor/descending
Surface
Basilar sulcus
Other grey: Raphe/
reticular

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

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