- Myeloid and erythroid nuclear termination stage-specific protein
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Myeloid and erythroid nuclear termination stage-specific protein (MENT) is a member of the serpin family of protease inhibitors, and participates in DNA and chromatin condensation.[1] Alongside its ability to condense chromatin, MENT is also an effective inhibitor of the proteases cathepsin K, cathepsin L, and cathepsin V, all of which are cysteine proteases.[2] As such, although MENT is structurally classified as a member of the serpin family, it is functionally termed a "cross-class inhibitor," as it is a cysteine rather than a serine protease inhibitor.
References
- ^ McGowan S, Buckle AM, Irving JA, et al. (July 2006). "X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation". EMBO J. 25 (13): 3144–55. doi:10.1038/sj.emboj.7601201. PMC 1500978. PMID 16810322. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1500978.
- ^ Irving JA, Shushanov SS, Pike RN, et al. (April 2002). "Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation". J. Biol. Chem. 277 (15): 13192–201. doi:10.1074/jbc.M108460200. PMID 11821386.
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inhibitory Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor
SERPINA1 · SERPINA2 · SERPINA3 · SERPINA4 · SERPINA5 · SERPINA6 · SERPINA7 · SERPINA8 · SERPINA9 · SERPINA14
SERPINB1 · SERPINB2 · SERPINB3 · SERPINB4 · SERPINB5 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13
SERPINC1 · SERPIND1 · SERPINE1 · SERPINE2 · SERPINE2 · SERPINF1 · SERPING1 · SERPINH1 · SERPINI1 · SERPINI2Cross class inhibitory MENT · SCCA-1 · crmAnoninhibitory see also disorders of globin and globulin proteins This protein-related article is a stub. You can help Wikipedia by expanding it.