dCTP deaminase (dUMP-forming)

dCTP deaminase (dUMP-forming)
DCTP deaminase (dUMP-forming)
Identifiers
EC number 3.5.4.30
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction

dCTP + 2 H2O \rightleftharpoons dUMP + diphosphate + NH3

Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.

References

  • Li H, Xu H, Graham DE, White RH (2003). "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278 (13): 11100–6. doi:10.1074/jbc.M212460200. PMID 12538648. 
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