Edward Tobinick

Edward Lewis Tobinick is an American physician currently in full-time private practice in Los Angeles, California and he is an Assistant Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA. [ [http://www.newsroom.ucla.edu/portal/ucla/ucla-headlines-jan-11-2008-43001.aspx UCLA Headlines Jan. 11, 2008 / UCLA Newsroom ] ] Dr. Tobinick is co-author of the recent case report documenting rapid clinical improvement in a patient with Alzheimer's disease following perispinal administration of etanercept [ [http://www.jneuroinflammation.com/content/5/1/2 Journal of Neuroinflammation | Full text | Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration ] ] which has been received with considerable interest [ [http://www.jneuroinflammation.com/content/5/1/3 Journal of Neuroinflammation | Full text | Perispinal etanercept: Potential as an Alzheimer therapeutic ] ] [ [http://www.newsroom.ucla.edu/portal/ucla/ucla-headlines-jan-11-2008-43001.aspx UCLA Headlines Jan. 11, 2008 / UCLA Newsroom ] ] .

Tobinick has been issued patents for methods of perispinal administration, of certain recombinant DNA-derived (biologic) therapeutics including the TNF receptor fusion protein etanercept, for the treatment of certain neurologic disorders with widespread unmet medical need, including Alzheimer's disease; pain due to cancer metastasis to bone; severe, intractable, intervertebral disc-related pain and radiculopathy (including sciatica); and myasthenia gravis. [ [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick United States Patent 6,423,321] ] In addition, he originated the concept of the potential utility of etanercept, alone or in combination with oseltamivir for treatment of influenza (U.S. patent 6,419,934, filed September 5, 2000 [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick] ). For these novel treatment methods he has been issued multiple U.S. patents, including 6,015,557 (Tumor necrosis factor antagonists for the treatment of neurological disorders) [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=41&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick] ; 6,177,077 [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=35&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick] ; 6,419,934 [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick] ; and 6,982,089 [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick] . In general, his concepts represent emerging therapeutic strategies supported by small pilot studies and expert reviews. (see 2007 Citations, below). [ [http://www.nrimed.com/bio.htm Tobinick's private practice] ]

Tobinick earned his M.D. from the UC San Diego School of Medicine in 1977.

Publications

*
*
*
*
*
*
*
*
* cite book
last = Tobinick | first = Edward
coauthors = Richard Usatine, Ronald Moy, Daniel Siegel
title = Skin Surgery: A Practical Guide
location = St. Louis
publisher = Mosby
year = 1998
id = ISBN 0-8151-7362-8

Citations

In 2007 the following scientific publications have cited Tobinick publications:Scientific Articles:
*1. Uceyler N, Sommer C. Cytokine-induced Pain: Basic Science and Clinical Implications. Reviews in Analgesia 2007;9(2):87-103.
*2. Tweedie D, Sambamurti K, Greig NH. Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, US. TNF-alpha Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets. Curr Alzheimer Res. 2007 Sep;4(4):375-8.
*2. Tubbs RS, Hansasuta A, Loukas M, Louis RG, Jr., Shoja MM, Salter EG, et al. The basilar venous plexus. Clin Anat 2007.
*3. Saxena AK, Kumar S. Management strategies for pain in breast carcinoma patients: current opinions and future perspectives. Pain Pract 2007;7(2):163-77.
*4. Owlia MB, Salimzadeh A, Alishiri G, Haghighi A. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain. Singapore Med J 2007;48(3):241-5.
*5. Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, et al. A novel p38alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation 2007;4(1):21.
*6. Hu W, Ranaivo HR, Roy SM, Behanna HA, Wing LK, Munoz L, et al. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorg Med Chem Lett 2007;17(2):414-8.
*7. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 2007 Aug 9;9(4):R77.

Hardcover/ Bound Texts:
*1. Neuroinflammation in Neuronal Death and Repair, Volume 82 (International Review of Neurobiology.) G. Bagetta, editor (Hardcover - Jul 16, 2007) Amsterdam ; Boston : Elsevier Academic Press ©2007. ISBN 9780123739896 0123739896.
*2. Interactions Between Neurons and Glia in Aging and Disease by Joao Malva, Ana Cristina Rego, Rodrigo Cunha, and Catarina Oliveira (Eds.) (Hardcover - Aug 22, 2007). 2007, Approx. 535 p., Hardcover ISBN 978-0-387-70829-4 New York ; London : Springer, 2007.
*3. Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development) by Michael A. Caligiuri and Michael T. Lotze (Hardcover - April 20, 2007) Totowa, N.J. : Humana Press ©2007. ISBN 9780896038202 0896038203 9781597454551 1597454559.
*4. Chapter 10: Anti-TNF-alpha antibody and cancer cachexia, The ASCRS Textbook of Colon and Rectal Surgery by J.M. Church, J. Garcia-Aguilar, P.L. Roberts, and T.J. Saclarides; New York : Springer ©2007. ISBN 9780387248462 0387248463.
*5. Spinal Reconstruction: Clinical Examples of Applied Basic Science, Biomechanics and Engineering by Kai-Uwe Lewandrowski, Michael J. Yaszemski, Iain Kalfas, and Paul Park (Hardcover - Feb 12, 2007) New York : Informa Healthcare ©2007. ISBN 9780849398155 0849398150.
*6. Olesen J, Jensen T. From Basic Pain Mechanisms to Headache. Oxford University Press 2007.
*7. Neuroimmunology: The Immune System and Alzheimers, in the 2007 Progress Report on Brain Research, Dana Alliance for Brain Initiatives, Dana Press, New York ©2007.

References

* [http://www.medscape.com/viewarticle/530141 link]

External links

* [http://www.tobinick.com/ Edward Tobinick]
* [http://www.nrimed.com/ Institute for Neurological Research, a private medical group, inc.]