MRPL10

Mitochondrial ribosomal protein L10, also known as MRPL10, is a human gene.cite web | title = Entrez Gene: MRPL10 mitochondrial ribosomal protein L10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124995| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.cite web | title = Entrez Gene: MRPL10 mitochondrial ribosomal protein L10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124995| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wang CC, Kadota M, Nishigaki R, "et al." |title=Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 2 |pages= 335-50 |year= 2004 |pmid= 14733910 |doi=
*cite journal | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468-80 |year= 2003 |pmid= 12706105 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koc EC, Burkhart W, Blackburn K, "et al." |title=The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43958-69 |year= 2001 |pmid= 11551941 |doi= 10.1074/jbc.M106510200
*cite journal | author=Kenmochi N, Suzuki T, Uechi T, "et al." |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65-70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622
*cite journal | author=Goldschmidt-Reisin S, Kitakawa M, Herfurth E, "et al." |title=Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34828-36 |year= 1999 |pmid= 9857009 |doi=
*cite journal | author=Piatyszek MA, Denslow ND, O'Brien TW |title=RNA binding proteins of the large subunit of bovine mitochondrial ribosomes. |journal=Nucleic Acids Res. |volume=16 |issue= 6 |pages= 2565-83 |year= 1988 |pmid= 3129699 |doi=

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