PRSS16

Protease, serine, 16 (thymus), also known as PRSS16, is a human gene.cite web | title = Entrez Gene: PRSS16 protease, serine, 16 (thymus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10279| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.cite web | title = Entrez Gene: PRSS16 protease, serine, 16 (thymus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10279| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lie BA, Viken MK, Akselsen HE, "et al." |title=Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease. |journal=Hum. Immunol. |volume=68 |issue= 7 |pages= 592-8 |year= 2007 |pmid= 17584581 |doi= 10.1016/j.humimm.2007.03.009
*cite journal | author=Luther C, Wienhold W, Oehlmann R, "et al." |title=Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus. |journal=Genes Immun. |volume=6 |issue= 1 |pages= 1-7 |year= 2005 |pmid= 15592422 |doi= 10.1038/sj.gene.6364142
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Lie BA, Akselsen HE, Bowlus CL, "et al." |title=Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases. |journal=Genes Immun. |volume=3 |issue= 5 |pages= 306-12 |year= 2003 |pmid= 12140752 |doi= 10.1038/sj.gene.6363858
*cite journal | author=Bowlus CL, Ahn J, Chu T, Gruen JR |title=Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. |journal=Cell. Immunol. |volume=196 |issue= 2 |pages= 80-6 |year= 1999 |pmid= 10527559 |doi= 10.1006/cimm.1999.1543
*cite journal | author=Gruen JR, Nalabolu SR, Chu TW, "et al." |title=A transcription map of the major histocompatibility complex (MHC) class I region. |journal=Genomics |volume=36 |issue= 1 |pages= 70-85 |year= 1997 |pmid= 8812418 |doi=

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