- PIR (gene)
Pirin (iron-binding nuclear protein), also known as PIR, is a human
gene .cite web | title = Entrez Gene: PIR pirin (iron-binding nuclear protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8544| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.cite web | title = Entrez Gene: PIR pirin (iron-binding nuclear protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8544| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Adams M, Jia Z |title=Structural and biochemical analysis reveal pirins to possess quercetinase activity. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28675-82 |year= 2005 |pmid= 15951572 |doi= 10.1074/jbc.M501034200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Pang H, Bartlam M, Zeng Q, "et al." |title=Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1491-8 |year= 2004 |pmid= 14573596 |doi= 10.1074/jbc.M310022200
*cite journal | author=Zeng Q, Li X, Bartlam M, "et al." |title=Purification, crystallization and preliminary X-ray analysis of human pirin. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=59 |issue= Pt 8 |pages= 1496-8 |year= 2004 |pmid= 12876364 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dechend R, Hirano F, Lehmann K, "et al." |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316-23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717
*cite journal | author=Wendler WM, Kremmer E, Förster R, Winnacker EL |title=Identification of pirin, a novel highly conserved nuclear protein. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8482-9 |year= 1997 |pmid= 9079676 |doi=PBB_Controls
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