SPRY4

Sprouty homolog 4 (Drosophila), also known as SPRY4, is a human gene.cite web | title = Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81848| accessdate = ]

PBB_Summary
section_title =
summary_text = SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002). [supplied by OMIM] cite web | title = Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81848| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zaharieva I, Georgieva L, Nikolov I, "et al." |title=Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. |journal=BMC psychiatry |volume=8 |issue= |pages= 11 |year= |pmid= 18298822 |doi= 10.1186/1471-244X-8-11
*cite journal | author=Cabrita MA, Jäggi F, Widjaja SP, Christofori G |title=A functional interaction between sprouty proteins and caveolin-1. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 29201-2912 |year= 2006 |pmid= 16877379 |doi= 10.1074/jbc.M603921200
*cite journal | author=Katoh Y, Katoh M |title=FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. |journal=Int. J. Mol. Med. |volume=17 |issue= 3 |pages= 529-32 |year= 2006 |pmid= 16465403 |doi=
*cite journal | author=Wang J, Thompson B, Ren C, "et al." |title=Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer. |journal=Prostate |volume=66 |issue= 6 |pages= 613-24 |year= 2006 |pmid= 16388505 |doi= 10.1002/pros.20353
*cite journal | author=Ding W, Bellusci S, Shi W, Warburton D |title=Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=287 |issue= 1 |pages= L52-9 |year= 2004 |pmid= 14977631 |doi= 10.1152/ajplung.00430.2003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sasaki A, Taketomi T, Kato R, "et al." |title=Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. |journal=Nat. Cell Biol. |volume=5 |issue= 5 |pages= 427-32 |year= 2003 |pmid= 12717443 |doi= 10.1038/ncb978
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leeksma OC, Van Achterberg TA, Tsumura Y, "et al." |title=Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. |journal=Eur. J. Biochem. |volume=269 |issue= 10 |pages= 2546-56 |year= 2002 |pmid= 12027893 |doi=

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