- RNF128
Ring finger protein 128, also known as RNF128, is a human
gene .cite web | title = Entrez Gene: RNF128 ring finger protein 128| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79589| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: RNF128 ring finger protein 128| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79589| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kostianovsky AM, Maier LM, Baecher-Allan C, "et al." |title=Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. |journal=J. Immunol. |volume=178 |issue= 10 |pages= 6158-63 |year= 2007 |pmid= 17475842 |doi=
*cite journal | author=MacKenzie DA, Schartner J, Lin J, "et al." |title=GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9696-702 |year= 2007 |pmid= 17259178 |doi= 10.1074/jbc.M604192200
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Soares L, Seroogy C, Skrenta H, "et al." |title=Two isoforms of otubain 1 regulate T cell anergy via GRAIL. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 45-54 |year= 2004 |pmid= 14661020 |doi= 10.1038/ni1017
*cite journal | author=Anandasabapathy N, Ford GS, Bloom D, "et al." |title=GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. |journal=Immunity |volume=18 |issue= 4 |pages= 535-47 |year= 2003 |pmid= 12705856 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899PBB_Controls
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