RCN2

RCN2

Reticulocalbin 2, EF-hand calcium binding domain, also known as RCN2, is a human gene.cite web | title = Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5955| accessdate = ]

PBB_Summary
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summary_text = Reticulocalbin 2 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. The RCN2 gene maps to the same region as type 4 Bardet-Biedl syndrome (MIM:600374), suggesting a possible causative role for reticulocalbin 2 in the disorder.cite web | title = Entrez Gene: RCN2 reticulocalbin 2, EF-hand calcium binding domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5955| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS |title=Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17786-92 |year= 2000 |pmid= 10748068 |doi= 10.1074/jbc.M002254200
*cite journal | author=Wang JY, Zhen DK, Bianchi DW, "et al." |title=Assignment of the gene for ERC-55 (RCN2) to human chromosome band 15q22.33-->q24.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 60-1 |year= 1998 |pmid= 9533013 |doi=
*cite journal | author=Dodds DC, Omeis IA, Cushman SJ, "et al." |title=Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21488-94 |year= 1997 |pmid= 9261167 |doi=
*cite journal | author=Weis K, Griffiths G, Lamond AI |title=The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. |journal=J. Biol. Chem. |volume=269 |issue= 29 |pages= 19142-50 |year= 1994 |pmid= 8034671 |doi=
*cite journal | author=Chen JJ, Reid CE, Band V, Androphy EJ |title=Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. |journal=Science |volume=269 |issue= 5223 |pages= 529-31 |year= 1995 |pmid= 7624774 |doi=

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  • EF hand — Pfam box Symbol = efhand Name = EF hand width = caption = Calmodulin with four EF Hand motifs. Pfam= PF00036 PROSITE=PDOC00018 InterPro= IPR002048 SMART= SCOP = 1osa TCDB = OPM family= OPM protein= 1djx PDB=PDB3|1s6jA:375 402 PDB3|1s6iA:375 403… …   Wikipedia

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