PCDHA1

Protocadherin alpha 1, also known as PCDHA1, is a human gene.cite web | title = Entrez Gene: PCDHA1 protocadherin alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56147| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.cite web | title = Entrez Gene: PCDHA1 protocadherin alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56147| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551-72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777
*cite journal | author=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169-80 |year= 2000 |pmid= 10817752 |doi=
*cite journal | author=Schmutz J, Martin J, Terry A, "et al." |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919
*cite journal | author=Wu Q, Zhang T, Cheng JF, "et al." |title=Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. |journal=Genome Res. |volume=11 |issue= 3 |pages= 389-404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124-9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397
*cite journal | author=Sugino H, Hamada S, Yasuda R, "et al." |title=Genomic organization of the family of CNR cadherin genes in mice and humans. |journal=Genomics |volume=63 |issue= 1 |pages= 75-87 |year= 2000 |pmid= 10662547 |doi= 10.1006/geno.1999.6066
*cite journal | author=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes. |journal=Cell |volume=97 |issue= 6 |pages= 779-90 |year= 1999 |pmid= 10380929 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes