TASP1

Taspase, threonine aspartase, 1, also known as TASP1, is a human gene.cite web | title = Entrez Gene: TASP1 taspase, threonine aspartase, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55617| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.cite web | title = Entrez Gene: TASP1 taspase, threonine aspartase, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55617| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhou H, Spicuglia S, Hsieh JJ, "et al." |title=Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. |journal=Mol. Cell. Biol. |volume=26 |issue= 7 |pages= 2728-35 |year= 2006 |pmid= 16537915 |doi= 10.1128/MCB.26.7.2728-2735.2006
*cite journal | author=Khan JA, Dunn BM, Tong L |title=Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. |journal=Structure |volume=13 |issue= 10 |pages= 1443-52 |year= 2006 |pmid= 16216576 |doi= 10.1016/j.str.2005.07.006
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hsieh JJ, Cheng EH, Korsmeyer SJ |title=Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. |journal=Cell |volume=115 |issue= 3 |pages= 293-303 |year= 2004 |pmid= 14636557 |doi=
*cite journal | author=Hsieh JJ, Ernst P, Erdjument-Bromage H, "et al." |title=Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 186-94 |year= 2003 |pmid= 12482972 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a

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