MEG3

Maternally expressed 3, also known as MEG3, is a human gene.cite web | title = Entrez Gene: MEG3 maternally expressed 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55384| accessdate = ]

PBB_Summary
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summary_text = MEG3 is a maternally expressed imprinted gene which appears to function as an RNA molecule; multiple splice variants are observed in the available sequence data and a pituitary transcript variant has been associated with inhibited cell proliferation. Studies in mouse and sheep suggest that an upstream intergenic differentially methylated region regulates imprinting imprinting of the region. The expression profile in mouse of the co-regulated Meg3/Gtl2 and Dlk1 genes suggests a causative role in the pathologies found in uniparental disomy animals, characterized by defects in skeletal muscle maturation, bone formation, placenta size and organization and prenatal lethality. The sheep homolog is associated with the callipyge mutation which in heterozygous individuals affects a muscle-specific long-range control element located in the DLK1-GTL2 intergenic region and results in the callipyge muscular hypertrophy. The non-Mendelian inheritance pattern, known as polar overdominance, likely results from the combination of the cis-effect on the expression levels of genes in the DLK1-GTL2 imprinted domain, and trans interaction between the products of reciprocally imprinted genes.cite web | title = Entrez Gene: MEG3 maternally expressed 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55384| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhou Y, Zhong Y, Wang Y, "et al." |title=Activation of p53 by MEG3 non-coding RNA. |journal=J. Biol. Chem. |volume=282 |issue= 34 |pages= 24731-42 |year= 2007 |pmid= 17569660 |doi= 10.1074/jbc.M702029200
*cite journal | author=Zhao J, Zhang X, Zhou Y, "et al." |title=Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region. |journal=Int. J. Biochem. Cell Biol. |volume=38 |issue= 10 |pages= 1808-20 |year= 2006 |pmid= 16793321 |doi= 10.1016/j.biocel.2006.05.004
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang X, Zhou Y, Mehta KR, "et al." |title=A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 11 |pages= 5119-26 |year= 2003 |pmid= 14602737 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Miyoshi N, Wagatsuma H, Wakana S, "et al." |title=Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. |journal=Genes Cells |volume=5 |issue= 3 |pages= 211-20 |year= 2000 |pmid= 10759892 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138

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