SKIP

SKIP

Skeletal muscle and kidney enriched inositol phosphatase, also known as SKIP, is a human gene.cite web | title = Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51763| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51763| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Drayer AL, Pesesse X, De Smedt F, "et al." |title=The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases. |journal=Biochem. Soc. Trans. |volume=24 |issue= 4 |pages= 1001-5 |year= 1997 |pmid= 8968500 |doi=
*cite journal | author=Mitchell CA, Brown S, Campbell JK, "et al." |title=Regulation of second messengers by the inositol polyphosphate 5-phosphatases. |journal=Biochem. Soc. Trans. |volume=24 |issue= 4 |pages= 994-1000 |year= 1997 |pmid= 8968499 |doi=
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Chen J, Xu J, Zhao W, "et al." |title=Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 11 |pages= 2273-83 |year= 2005 |pmid= 16002321 |doi= 10.1016/j.biocel.2005.02.028
*cite journal | author=Cardoso C, Leventer RJ, Ward HL, "et al." |title=Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. |journal=Am. J. Hum. Genet. |volume=72 |issue= 4 |pages= 918-30 |year= 2003 |pmid= 12621583 |doi=
*cite journal | author=Ijuin T, Takenawa T |title=SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. |journal=Mol. Cell. Biol. |volume=23 |issue= 4 |pages= 1209-20 |year= 2003 |pmid= 12556481 |doi=
*cite journal | author=Gurung R, Tan A, Ooms LM, "et al." |title=Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11376-85 |year= 2003 |pmid= 12536145 |doi= 10.1074/jbc.M209991200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ijuin T, Mochizuki Y, Fukami K, "et al." |title=Identification and characterization of a novel inositol polyphosphate 5-phosphatase. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10870-5 |year= 2000 |pmid= 10753883 |doi=

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