VCX

Variable charge, X-linked, also known as VCX, is a human gene.cite web | title = Entrez Gene: VCX variable charge, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.cite web | title = Entrez Gene: VCX variable charge, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zou SW, Zhang JC, Zhang XD, "et al." |title=Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. |journal=Cell Res. |volume=13 |issue= 3 |pages= 171-7 |year= 2004 |pmid= 12862317 |doi= 10.1038/sj.cr.7290161
*cite journal | author=Sy SM, Wong N, Mok TS, "et al." |title=Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. |journal=Lung Cancer |volume=41 |issue= 1 |pages= 91-9 |year= 2003 |pmid= 12826317 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fukami M, Kirsch S, Schiller S, "et al." |title=A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. |journal=Am. J. Hum. Genet. |volume=67 |issue= 3 |pages= 563-73 |year= 2000 |pmid= 10903929 |doi=
*cite journal | author=Lahn BT, Page DC |title=A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 2 |pages= 311-9 |year= 2000 |pmid= 10607842 |doi=

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