PIGP

Phosphatidylinositol glycan anchor biosynthesis, class P, also known as PIGP, is a human gene.cite web | title = Entrez Gene: PIGP phosphatidylinositol glycan anchor biosynthesis, class P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51227| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: PIGP phosphatidylinositol glycan anchor biosynthesis, class P| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51227| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ferrando-Miguel R, Cheon MS, Lubec G |title=Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5). |journal=Amino Acids |volume=26 |issue= 3 |pages= 255-61 |year= 2005 |pmid= 15221505 |doi= 10.1007/s00726-004-0065-9
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Choi DK, Suzuki Y, Yoshimura S, "et al." |title=Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5). |journal=Mamm. Genome |volume=12 |issue= 5 |pages= 347-51 |year= 2001 |pmid= 11331941 |doi= 10.1007/s003350010283
*cite journal | author=Watanabe R, Murakami Y, Marmor MD, "et al." |title=Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4402-11 |year= 2000 |pmid= 10944123 |doi= 10.1093/emboj/19.16.4402
*cite journal | author=Togashi T, Choi DK, Taylor TD, "et al." |title=A novel gene, DSCR5, from the distal Down syndrome critical region on chromosome 21q22.2. |journal=DNA Res. |volume=7 |issue= 3 |pages= 207-12 |year= 2001 |pmid= 10907851 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Shibuya K, Kudoh J, Minoshima S, "et al." |title=Isolation of two novel genes, DSCR5 and DSCR6, from Down syndrome critical region on human chromosome 21q22.2. |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 3 |pages= 693-8 |year= 2000 |pmid= 10814524 |doi= 10.1006/bbrc.2000.2685

PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes