STEAP2

Six transmembrane epithelial antigen of the prostate 2, also known as STEAP2, is a human gene.cite web | title = Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=261729| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=261729| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Denoeud F, Kapranov P, Ucla C, "et al." |title=Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. |journal=Genome Res. |volume=17 |issue= 6 |pages= 746–59 |year= 2007 |pmid= 17567994 |doi= 10.1101/gr.5660607
*cite journal | author=Ohgami RS, Campagna DR, McDonald A, Fleming MD |title=The Steap proteins are metalloreductases. |journal=Blood |volume=108 |issue= 4 |pages= 1388–94 |year= 2006 |pmid= 16609065 |doi= 10.1182/blood-2006-02-003681
*cite journal | author=Korkmaz CG, Korkmaz KS, Kurys P, "et al." |title=Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. |journal=Oncogene |volume=24 |issue= 31 |pages= 4934–45 |year= 2005 |pmid= 15897894 |doi= 10.1038/sj.onc.1208677
*cite journal | author=Sanchez-Pulido L, Rojas AM, Valencia A, "et al." |title=ACRATA: a novel electron transfer domain associated to apoptosis and cancer. |journal=BMC Cancer |volume=4 |issue= |pages= 98 |year= 2005 |pmid= 15623366 |doi= 10.1186/1471-2407-4-98
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Porkka KP, Helenius MA, Visakorpi T |title=Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. |journal=Lab. Invest. |volume=82 |issue= 11 |pages= 1573–82 |year= 2002 |pmid= 12429817 |doi=
*cite journal | author=Korkmaz KS, Elbi C, Korkmaz CG, "et al." |title=Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36689–96 |year= 2002 |pmid= 12095985 |doi= 10.1074/jbc.M202414200
*cite journal | author=Walker MG, Volkmuth W, Sprinzak E, "et al." |title=Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. |journal=Genome Res. |volume=9 |issue= 12 |pages= 1198–203 |year= 2000 |pmid= 10613842 |doi=

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