TAC4

Tachykinin 4 (hemokinin), also known as TAC4, is a human gene.cite web | title = Entrez Gene: TAC4 tachykinin 4 (hemokinin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=255061| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: TAC4 tachykinin 4 (hemokinin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=255061| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Page NM |title=Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides. |journal=Vascul. Pharmacol. |volume=45 |issue= 4 |pages= 200–8 |year= 2007 |pmid= 16931167 |doi= 10.1016/j.vph.2005.08.028
*cite journal | author=Page NM |title=Hemokinins and endokinins. |journal=Cell. Mol. Life Sci. |volume=61 |issue= 13 |pages= 1652–63 |year= 2004 |pmid= 15224188 |doi= 10.1007/s00018-004-4035-x
*cite journal | author=Cunningham S, O'Doherty C, Patterson C, "et al." |title=The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. |journal=J. Neuroimmunol. |volume=183 |issue= 1-2 |pages= 208–13 |year= 2007 |pmid= 17175032 |doi= 10.1016/j.jneuroim.2006.11.002
*cite journal | author=Page NM, Bell NJ, Gardiner SM, "et al." |title=Characterization of the endokinins: human tachykinins with cardiovascular activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6245–50 |year= 2003 |pmid= 12716968 |doi= 10.1073/pnas.0931458100
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kurtz MM, Wang R, Clements MK, "et al." |title=Identification, localization and receptor characterization of novel mammalian substance P-like peptides. |journal=Gene |volume=296 |issue= 1-2 |pages= 205–12 |year= 2003 |pmid= 12383518 |doi=
*cite journal | author=Bellucci F, Carini F, Catalani C, "et al." |title=Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. |journal=Br. J. Pharmacol. |volume=135 |issue= 1 |pages= 266–74 |year= 2002 |pmid= 11786503 |doi= 10.1038/sj.bjp.0704443
*cite journal | author=Zhang Y, Lu L, Furlonger C, "et al." |title=Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. |journal=Nat. Immunol. |volume=1 |issue= 5 |pages= 392–7 |year= 2001 |pmid= 11062498 |doi= 10.1038/80826
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=

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