ATG4A

ATG4 autophagy related 4 homolog A (S. cerevisiae), also known as ATG4A, is a human gene.cite web | title = Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115201| accessdate = ]

PBB_Summary
section_title =
summary_text = Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.cite web | title = Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115201| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scherz-Shouval R, Shvets E, Fass E, "et al." |title=Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. |journal=EMBO J. |volume=26 |issue= 7 |pages= 1749–60 |year= 2007 |pmid= 17347651 |doi= 10.1038/sj.emboj.7601623
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kabeya Y, Mizushima N, Yamamoto A, "et al." |title=LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 13 |pages= 2805–12 |year= 2005 |pmid= 15169837 |doi= 10.1242/jcs.01131
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z |title=The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14053–8 |year= 2003 |pmid= 12473658 |doi= 10.1074/jbc.M212108200
*cite journal | author=Mariño G, Uría JA, Puente XS, "et al." |title=Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 3671–8 |year= 2003 |pmid= 12446702 |doi= 10.1074/jbc.M208247200

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