RNF139

Ring finger protein 139, also known as RNF139, is a human gene.cite web | title = Entrez Gene: RNF139 ring finger protein 139| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11236| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.cite web | title = Entrez Gene: RNF139 ring finger protein 139| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11236| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Poland KS, Azim M, Folsom M, "et al." |title=A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. |journal=Genes Chromosomes Cancer |volume=46 |issue= 9 |pages= 805–12 |year= 2007 |pmid= 17539022 |doi= 10.1002/gcc.20466
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Brauweiler A, Lorick KL, Lee JP, "et al." |title=RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. |journal=Oncogene |volume=26 |issue= 16 |pages= 2263–71 |year= 2007 |pmid= 17016439 |doi= 10.1038/sj.onc.1210017
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gemmill RM, Bemis LT, Lee JP, "et al." |title=The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. |journal=Oncogene |volume=21 |issue= 22 |pages= 3507–16 |year= 2002 |pmid= 12032852 |doi= 10.1038/sj.onc.1205437
*cite journal | author=Lorick KL, Jensen JP, Fang S, "et al." |title=RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11364–9 |year= 1999 |pmid= 10500182 |doi=
*cite journal | author=Gemmill RM, West JD, Boldog F, "et al." |title=The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9572–7 |year= 1998 |pmid= 9689122 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=

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