ACTL7A

Actin-like 7A, also known as ACTL7A, is a human gene.cite web | title = Entrez Gene: ACTL7A actin-like 7A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10881| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.cite web | title = Entrez Gene: ACTL7A actin-like 7A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10881| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schafer DA, Schroer TA |title=Actin-related proteins. |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |issue= |pages= 341–63 |year= 2000 |pmid= 10611965 |doi= 10.1146/annurev.cellbio.15.1.341
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Garvalov BK, Higgins TE, Sutherland JD, "et al." |title=The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. |journal=J. Cell Biol. |volume=161 |issue= 1 |pages= 33–9 |year= 2003 |pmid= 12695497 |doi= 10.1083/jcb.200211015
*cite journal | author=Coutts AS, MacKenzie E, Griffith E, Black DM |title=TES is a novel focal adhesion protein with a role in cell spreading. |journal=J. Cell. Sci. |volume=116 |issue= Pt 5 |pages= 897–906 |year= 2003 |pmid= 12571287 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chadwick BP, Mull J, Helbling LA, "et al." |title=Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31. |journal=Genomics |volume=58 |issue= 3 |pages= 302–9 |year= 1999 |pmid= 10373328 |doi= 10.1006/geno.1999.5848

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