Cornification

Cornification

Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.

At cellular level cornification is characterised by

* production of keratin
* production of small proline-rich (SPRR) proteins and transglutaminase which eventually form a cornified cell envelope beneath the plasma membrane
* terminal differentiation
* loss of nuclei and organelles, in the final stages of cornification metabolism ceases and the cells are completely filled by keratin

Sources: Harvcoltxt |Matsuda |Osaki |Hashii |Koshiba |2007 and Harvcoltxt |Steinert |Kartasova |Marekov |1998 .

ee also

* Keratin and Cornification

References

* cite journal |author=Matsuda Y, Osaki T, Hashii T, Koshiba T, Kawabata S |title=A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites |journal=J. Biol. Chem. |volume=282 |issue=46 |pages=33545–52 |year=2007 |month=November |pmid=17855345 |doi=10.1074/jbc.M705854200 |url=
* cite journal |author=Steinert PM, Kartasova T, Marekov LN |title=Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes |journal=J. Biol. Chem. |volume=273 |issue=19 |pages=11758–69 |year=1998 |month=May |pmid=9565599 |doi= |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9565599


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Look at other dictionaries:

  • Cornification — Cor ni*fi*ca tion (k?r n? f? k? sh?n), n. Conversion into, or formation of, horn; a becoming like horn. [1913 Webster] …   The Collaborative International Dictionary of English

  • cornification — noun Etymology: Latin cornu horn Date: circa 1843 conversion into horn or a horny or keratinous substance or tissue …   New Collegiate Dictionary

  • cornification — conversion into horny tissue; hardening …   Dictionary of ichthyology

  • cornification — n. [L. dim. cornu, horn; facere, to make] Formation of horn or horn like material; keratinization …   Dictionary of invertebrate zoology

  • cornification — /kawr neuh fi kay sheuhn/, n. Biol. the formation of a horny layer of skin, or horny skin structures, as hair, nails, or scales, from squamous epithelial cells. [1835 45; CORN2 + I + FICATION] * * * …   Universalium

  • cornification — noun Conversion into, or formation of, horn; a becoming like horn …   Wiktionary

  • cornification — SYN: keratinization. [L. cornu, horn, + facio, to make] * * * cor·ni·fi·ca·tion .kȯr nə fə kā shən n 1) conversion into horn or a horny substance or tissue 2) the histological and cytological changes that occur in the vaginal epithelium esp. of… …   Medical dictionary

  • cornification — cor·ni·fi·ca·tion …   English syllables

  • cornification — n.; see keratinization …   The new mediacal dictionary

  • cornification — cor•ni•fi•ca•tion [[t]ˌkɔr nə fɪˈkeɪ ʃən[/t]] n. phl biochem. the formation of a horny layer of skin, or horny skin structures, as hair, nails, or scales, from squamous epithelial cells • Etymology: 1835–45; corn II+ i + fication …   From formal English to slang

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