Poly(N-isopropylacrylamide)

Chemical structure of poly(N-isopropylacrylamide)

Poly(N-isopropylacrylamide) (variously abbreviated PNIPA, PNIPAAm, PNIPAA or PNIPAm) is a temperature-responsive polymer that was first synthesized in the 1950s.^[1] It can be synthesized from NIPAM which is commercially available.

It forms a three-dimensional hydrogel when crosslinked with N,N’-methylene-bis-acrylamide (MBAm) or N,N’-cystamine-bis-acrylamide (CBAm). When heated in water above 32°C, it undergoes a reversible lower critical solution temperature phase transition from a swollen hydrated state to a shrunken dehydrated state, losing about 90% of its mass. In dilute solution, it undergoes a corresponding coil-to-globule transition at similar conditions)^[2].. Since PNIPAm expels its liquid contents at a temperature near that of the human body, PNIPAm has been investigated by many researchers for possible applications in tissue engineering ^[3][4] and controlled drug delivery.^[5][6][7] The renal glomerular filtration cut-off of copolymers of PNIPAm is situated around 32,000 g/mol.^[8]

References

1. ^ Schild, H. G. “Poly(N-isopropylacrylamide): experiment, theory and application” Progress in Polymer Science, 1992, 17 (2), 163–249.
2. ^ Wu, C; Wang X (1998). "Globule-to-Coil Transition of a Single Homopolymer Chain in Solution". Physical Review Letters 80 (18): 4092–4094. http://ludfc39.u-strasbg.fr/pdflib/polymers/collapse/1998_wu_wang.pdf. Retrieved 25 September 2010. 
3. ^ von Recum, HA.; Kim, SW. (1998). "Retinal pigmented epithelium cultures on thermally responsive polymer porous substrates". J Biomater Sci Polym Ed 9: 1241–1253. doi:10.1163/156856298X00758. http://www.ingentaconnect.com/content/vsp/bsp/1998/00000009/00000011/art00009?token=004e12baee383a4b3b2570497b607b406a4d2c6b67212a726e2d2954496f642f466f193f105cfe. 
4. ^ Lee, EL.; von Recum, HA (2010). "Cell culture platform with mechanical conditioning and nondamaging cellular detachment". J Biomed Mater Res A 93: 411–8. http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=PubMed&issn=1549-3296&title=J%20Biomed%20Mater%20Res%20A&volume=93&issue=2&spage=411&atitle=Cell%20culture%20platform%20with%20mechanical%20conditioning%20and%20nondamaging%20cellular%20detachment.&aulast=Lee&date=2010. 
5. ^ Chung, J. E.; Yokoyama, M.; Yamato, M.; Aoyagi, T.; Sakurai, Y.; Okano, T. “Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)” Journal of Controlled Release, 1999, 62, 115–127. Abstract
6. ^ Hu Yan and Kaoru Tsujii. “Potential application of poly(N-isopropylacrylamide) gel containing polymeric micelles to drug delivery systems” Colloids and Surfaces B: Biointerfaces. 2005, 46, 142–146. Abstract
7. ^ Antunes F. , Gentile L. , Tavano L. , Oliviero Rossi C. , " Rheological characterization of the thermal gelation of poly(N-isopropylacrylamide) and poly(N-isopropylacrylamide)co-Acrylic Acid". Applied Rheology, 2009, Vol. 19, n. 4, pp. 42064-42069. Abstract
8. ^ Bertrand, N.; Fleischer, J.G.; Wasan, K.M.; Leroux, J.C. (2009) Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes. Biomaterials, 30, 2598-2605 Abstract

This article about polymer science is a stub. You can help Wikipedia by expanding it.v · Categories: Polymers Polymer stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Claudius Ash 2008 Kansas State Wildcats football team Look at other dictionaries: Poly(N-isopropylacrylamide) — Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un polymère thermosensible qui en… …   Wikipédia en Français Poly(NIPAM) — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français (C6H11NO)n — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français 25189-55-3 — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français PNIPAAm — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français PNIPAM — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français PolyNIPAM — Poly(N isopropylacrylamide) Structure du poly(N isopropylacrylamide). La structure entre crochets constitue, en se répétant, le squelette des chaînons du polymère. Le poly(N isopropylacrylamide) (abrégé en polyNIPAM, PNIPAM ou PNIPAAm) est un… …   Wikipédia en Français Temperature-responsive polymer — A temperature responsive polymer is a polymer which undergoes a physical change when external thermal stimuli are presented. The ability to undergo such changes under easily controlled conditions makes this class of polymers fall into the… …   Wikipedia Nerve guidance conduit — A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical… …   Wikipedia Coil-globule transition — In polymer physics, the Coil globule transition is the collapse of a macromolecule from an expanded coil state through an ideal coil state to a collapsed globule state, or vice versa. The coil globule transition is of importance in biology due to …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”